Effects of chronic heroin addiction on pituitary-thyroid function in man

Francesca Brambilla, P. Nobile, A. Zanoboni, W. Zanoboni-Muciaccia, P. L. Meroni

Research output: Contribution to journalArticlepeer-review


Pituitary-thyroid function has been studied in heroin addicts. Data have been obtained in 10 male addicts, aged 18-24 years, with histories of addiction to heroin alone lasting from 8 months to 4 years, and in 9 controls matched for sex and age. Basal plasma levels of TSH,T4 and T3 were measured. A TRH stimulation test was done, injecting 500μg of TRH iv as a bolus and assaying TSH levels before the injection and at 30 min intervals up to 2 h afterwards. The results revealed no difference between addicts and controls in basal levels of TSH,T4 and T3. The TRH stimulation test induced a blunted TSH rise in 50% of the cases. The possible mechanism of action of heroin on pituitary-thyroid axis is discussed.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number3
Publication statusPublished - 1980


  • Heroin
  • T
  • T
  • thryrotropin
  • thyrotropin releasing hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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