TY - JOUR
T1 - Effects of chronic retinoid administration on pituitary function
AU - Angioni, A. R.
AU - Lania, A.
AU - Cattaneo, A.
AU - Beck-Peccoz, P.
AU - Spada, A.
PY - 2005
Y1 - 2005
N2 - It has been reported that retinoids may affect hypothalamic-pituitary- thyroid axis, causing central hypothyroidism. In the present study, we evaluated pituitary function in 11 male psoriatic patients at baseline and after 1 and 3 months of treatment with acitretin (all-trans retinoic acid, 35 mg/day). Serum LH, FSH, testosterone, cortisol, GH and IGF-I levels were not affected by the treatment. By contrast, we observed a significant decrease in TSH levels (from 0.92±0.3 to 0.80±0.3 mU/l, p4 (FT4) levels occurred, while free T3 (FT3) levels were reduced at 1 and 3 months (from 6.7±0.5 to 6.2±0.3 and 6.1±0.6 pmol/l; p3, probably due to changes in thyroid hormone metabolism, and a decrease in PRL levels.
AB - It has been reported that retinoids may affect hypothalamic-pituitary- thyroid axis, causing central hypothyroidism. In the present study, we evaluated pituitary function in 11 male psoriatic patients at baseline and after 1 and 3 months of treatment with acitretin (all-trans retinoic acid, 35 mg/day). Serum LH, FSH, testosterone, cortisol, GH and IGF-I levels were not affected by the treatment. By contrast, we observed a significant decrease in TSH levels (from 0.92±0.3 to 0.80±0.3 mU/l, p4 (FT4) levels occurred, while free T3 (FT3) levels were reduced at 1 and 3 months (from 6.7±0.5 to 6.2±0.3 and 6.1±0.6 pmol/l; p3, probably due to changes in thyroid hormone metabolism, and a decrease in PRL levels.
KW - Hypothyroidism
KW - Pituitary
KW - PRL
KW - Retinoids
UR - http://www.scopus.com/inward/record.url?scp=33144478283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33144478283&partnerID=8YFLogxK
M3 - Article
C2 - 16483172
VL - 28
SP - 961
EP - 964
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 11
ER -