Effects of chronic retinoid administration on pituitary function

A. R. Angioni, A. Lania, A. Cattaneo, P. Beck-Peccoz, A. Spada

Research output: Contribution to journalArticlepeer-review


It has been reported that retinoids may affect hypothalamic-pituitary- thyroid axis, causing central hypothyroidism. In the present study, we evaluated pituitary function in 11 male psoriatic patients at baseline and after 1 and 3 months of treatment with acitretin (all-trans retinoic acid, 35 mg/day). Serum LH, FSH, testosterone, cortisol, GH and IGF-I levels were not affected by the treatment. By contrast, we observed a significant decrease in TSH levels (from 0.92±0.3 to 0.80±0.3 mU/l, p4 (FT4) levels occurred, while free T3 (FT3) levels were reduced at 1 and 3 months (from 6.7±0.5 to 6.2±0.3 and 6.1±0.6 pmol/l; p3, probably due to changes in thyroid hormone metabolism, and a decrease in PRL levels.

Original languageEnglish
Pages (from-to)961-964
Number of pages4
JournalJournal of Endocrinological Investigation
Issue number11
Publication statusPublished - 2005


  • Hypothyroidism
  • Pituitary
  • PRL
  • Retinoids

ASJC Scopus subject areas

  • Endocrinology


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