Effetti sul sonno notturno e sulla sonnolenza diurna del trattamento cronico con Lamotrigina

Translated title of the contribution: Effects of chronic treatment with Lamotrigine on nocturnal sleep and daytime sleepiness

F. Placidi, M. Diomedi, G. Silvestri, A. Scalise, M. Maschio, M. G. Marciani, G. L. Gigli

Research output: Contribution to journalArticlepeer-review

Abstract

Lamotrigine (LTG) is a new antiepileptic drug, currently used in medically intractable patients. We studied nocturnal sleep and daytime somnolence in 13 patients undergoing add-on therapy with LTG for seizures resistant to common antiepileptic drugs (AEDs). LTG caused a significant increase of REM sleep and a significant decrease of SWS, of the number of stage shifts and of the number of entries in REM. No significant changes were observed in daytime sleepiness and cognitive functions after 3 months of treatment. The increased stability of nocturnal sleep could play an important role in the anticonvulsant effect of LTG.

Translated title of the contributionEffects of chronic treatment with Lamotrigine on nocturnal sleep and daytime sleepiness
Original languageItalian
Pages (from-to)221-222
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number95-96
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Clinical Neurology

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