Effetti sul sonno notturno e sulla sonnolenza diurna del trattamento cronico con Lamotrigina

F. Placidi; M. Diomedi; G. Silvestri; A. Scalise; M. Maschio; M. G. Marciani; G. L. Gigli

Effetti sul sonno notturno e sulla sonnolenza diurna del trattamento cronico con Lamotrigina

Translated title of the contribution: Effects of chronic treatment with Lamotrigine on nocturnal sleep and daytime sleepiness

F. Placidi, M. Diomedi, G. Silvestri, A. Scalise, M. Maschio, M. G. Marciani, G. L. Gigli

Research output: Contribution to journal › Article › peer-review

Abstract

Lamotrigine (LTG) is a new antiepileptic drug, currently used in medically intractable patients. We studied nocturnal sleep and daytime somnolence in 13 patients undergoing add-on therapy with LTG for seizures resistant to common antiepileptic drugs (AEDs). LTG caused a significant increase of REM sleep and a significant decrease of SWS, of the number of stage shifts and of the number of entries in REM. No significant changes were observed in daytime sleepiness and cognitive functions after 3 months of treatment. The increased stability of nocturnal sleep could play an important role in the anticonvulsant effect of LTG.

Translated title of the contribution	Effects of chronic treatment with Lamotrigine on nocturnal sleep and daytime sleepiness
Original language	Italian
Pages (from-to)	221-222
Number of pages	2
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	95-96
Publication status	Published - 1996

ASJC Scopus subject areas

Clinical Neurology

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title = "Effetti sul sonno notturno e sulla sonnolenza diurna del trattamento cronico con Lamotrigina",

abstract = "Lamotrigine (LTG) is a new antiepileptic drug, currently used in medically intractable patients. We studied nocturnal sleep and daytime somnolence in 13 patients undergoing add-on therapy with LTG for seizures resistant to common antiepileptic drugs (AEDs). LTG caused a significant increase of REM sleep and a significant decrease of SWS, of the number of stage shifts and of the number of entries in REM. No significant changes were observed in daytime sleepiness and cognitive functions after 3 months of treatment. The increased stability of nocturnal sleep could play an important role in the anticonvulsant effect of LTG.",

keywords = "Daytime sleepiness, Lamotrigine, Sleep",

author = "F. Placidi and M. Diomedi and G. Silvestri and A. Scalise and M. Maschio and Marciani, {M. G.} and Gigli, {G. L.}",

year = "1996",

language = "Italian",

pages = "221--222",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

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number = "95-96",

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T1 - Effetti sul sonno notturno e sulla sonnolenza diurna del trattamento cronico con Lamotrigina

AU - Placidi, F.

AU - Diomedi, M.

AU - Silvestri, G.

AU - Scalise, A.

AU - Maschio, M.

AU - Marciani, M. G.

AU - Gigli, G. L.

PY - 1996

Y1 - 1996

N2 - Lamotrigine (LTG) is a new antiepileptic drug, currently used in medically intractable patients. We studied nocturnal sleep and daytime somnolence in 13 patients undergoing add-on therapy with LTG for seizures resistant to common antiepileptic drugs (AEDs). LTG caused a significant increase of REM sleep and a significant decrease of SWS, of the number of stage shifts and of the number of entries in REM. No significant changes were observed in daytime sleepiness and cognitive functions after 3 months of treatment. The increased stability of nocturnal sleep could play an important role in the anticonvulsant effect of LTG.

AB - Lamotrigine (LTG) is a new antiepileptic drug, currently used in medically intractable patients. We studied nocturnal sleep and daytime somnolence in 13 patients undergoing add-on therapy with LTG for seizures resistant to common antiepileptic drugs (AEDs). LTG caused a significant increase of REM sleep and a significant decrease of SWS, of the number of stage shifts and of the number of entries in REM. No significant changes were observed in daytime sleepiness and cognitive functions after 3 months of treatment. The increased stability of nocturnal sleep could play an important role in the anticonvulsant effect of LTG.

KW - Daytime sleepiness

KW - Lamotrigine

KW - Sleep

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JO - Bollettino - Lega Italiana contro l'Epilessia

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