Clonidine, injected i.p. 20 min before cold exposure, is able to counteract the blockade induced by α-methyl-p-tyrosine of cold-stimulated release of TSH in rats. Under basal conditions the α-adrenoceptor stimulating agent, administered into the lateral cerebral ventricle (10 μg), produces, at 30 min, a sharp increase in plasma TSH that returns to control levels at 60 min. When the drug is given intraperitoneally (0.4 mg/kg) it causes a significant decrease in plasma TSH 120 min after the treatment.
|Number of pages||5|
|Journal||Archives Internationales de Pharmacodynamie et de Therapie|
|Publication status||Published - 1977|
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