Effects of clonidine on basal and cold-stimulated TSH secretion

U. Scapagnini, L. Annunziato, G. F. Di Renzo, G. Schettini, P. Preziosi

Research output: Contribution to journalArticlepeer-review


Clonidine, injected i.p. 20 min before cold exposure, is able to counteract the blockade induced by α-methyl-p-tyrosine of cold-stimulated release of TSH in rats. Under basal conditions the α-adrenoceptor stimulating agent, administered into the lateral cerebral ventricle (10 μg), produces, at 30 min, a sharp increase in plasma TSH that returns to control levels at 60 min. When the drug is given intraperitoneally (0.4 mg/kg) it causes a significant decrease in plasma TSH 120 min after the treatment.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalArchives Internationales de Pharmacodynamie et de Therapie
Issue number2
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology


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