Effects of clonidine on basal and cold-stimulated TSH secretion

U. Scapagnini, L. Annunziato, G. F. Di Renzo, G. Schettini, P. Preziosi

Research output: Contribution to journalArticle

Abstract

Clonidine, injected i.p. 20 min before cold exposure, is able to counteract the blockade induced by α-methyl-p-tyrosine of cold-stimulated release of TSH in rats. Under basal conditions the α-adrenoceptor stimulating agent, administered into the lateral cerebral ventricle (10 μg), produces, at 30 min, a sharp increase in plasma TSH that returns to control levels at 60 min. When the drug is given intraperitoneally (0.4 mg/kg) it causes a significant decrease in plasma TSH 120 min after the treatment.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume230
Issue number2
Publication statusPublished - 1977

Fingerprint

Clonidine
Cerebral Ventricles
Lateral Ventricles
Adrenergic Receptors
Tyrosine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Scapagnini, U., Annunziato, L., Di Renzo, G. F., Schettini, G., & Preziosi, P. (1977). Effects of clonidine on basal and cold-stimulated TSH secretion. Archives Internationales de Pharmacodynamie et de Therapie, 230(2), 220-224.

Effects of clonidine on basal and cold-stimulated TSH secretion. / Scapagnini, U.; Annunziato, L.; Di Renzo, G. F.; Schettini, G.; Preziosi, P.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 230, No. 2, 1977, p. 220-224.

Research output: Contribution to journalArticle

Scapagnini, U, Annunziato, L, Di Renzo, GF, Schettini, G & Preziosi, P 1977, 'Effects of clonidine on basal and cold-stimulated TSH secretion', Archives Internationales de Pharmacodynamie et de Therapie, vol. 230, no. 2, pp. 220-224.
Scapagnini, U. ; Annunziato, L. ; Di Renzo, G. F. ; Schettini, G. ; Preziosi, P. / Effects of clonidine on basal and cold-stimulated TSH secretion. In: Archives Internationales de Pharmacodynamie et de Therapie. 1977 ; Vol. 230, No. 2. pp. 220-224.
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