Effects of combined spinal-epidural analgesia on first stage of labor: a cohort study

Silvia Poma, Luigia Scudeller, Chiara Verga, Giorgio Mirabile, Barbara Gardella, Federica Broglia, Maria Ciceri, Marinella Fuardo, Simona Pellicori, Maddalena Gerletti, Silvia Zizzi, Elena Masserini, Maria Paola Delmonte, Giorgio Antonio Iotti

Research output: Contribution to journalArticlepeer-review


Background: Neuraxial anesthesia is considered as the gold standard in the control labor of pain. Its variants are epidural analgesia and combined spinal-epidural analgesia. Few studies, as yet, have investigated the duration of labor as a primary outcome. Some authors have suggested that combined spinal-epidural analgesia may reduce labor duration but at the moment the benefit of shortening labor is uncertain. The main aim of this study was to compare combined spinal-epidural with epidural analgesia in terms of their effect on duration of stage I labor, maternal, and neonatal outcomes. Methods: A prospective cohort study was conducted. Parturients who requested analgesia at cervical dilatation
Original languageEnglish
Pages (from-to)3559-3565
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number21
Publication statusPublished - Nov 2019


  • Augmentation of labor
  • fetal monitoring
  • labor analgesia
  • labor duration
  • Adult
  • *Analgesia, Epidural/methods
  • Analgesia, Obstetrical/*methods
  • Anesthesia, Epidural/methods
  • *Anesthesia, Spinal/methods
  • Cohort Studies
  • Combined Modality Therapy
  • Female
  • Heart Rate, Fetal/drug effects
  • Humans
  • Labor Stage, First/*drug effects/physiology
  • Labor, Obstetric/drug effects/physiology
  • Pregnancy
  • Pregnancy Outcome
  • Young Adult


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