Effects of continuing or stopping exposure to risk factors on natural history of laryngeal precancerous lesions

G. Succo, G. Valente, F. Riva, P. Gabriele, C. F. Gervasio, M. Airoldi, R. Ragona, G. Cortesina, A. Sartorisi

Research output: Contribution to journalArticlepeer-review


Background. The process of laryngeal carcinogenesis often develops through quite slow steps (precancerous lesions) and is influenced by various risk factors, the most important being tobacco smoke and alcohol consumption. Methods. In this study (including 216 men) we wanted to investigate wether continuing or stopping exposure to tobacco smoke and alcohol consumption would modify the natural history of such lesions in patients not treated other than by decortication of the true vocal cords for precancerous lesions, classified in accordance with the scale recommended by Hellquist: class 1 (mild dysplasia), class 2 (moderate dysplasia), class 3 (severe dysplasia - carcinoma in situ). Results. In all 3 classes; the differences of clinical evolution between patients who stopped exposure to such risk factors after first decortication and patients who did not stop, was statistically significant with no evidence of disease at 60 months in 90.3% and 47.3% of cases respectively Conclusions. We have noted a statistically significant correlation between exposition to smoking plus alcohol and class of dysplasia and between class of dysplasia and risk of recurrence and progression into invasive carcinoma.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalCancer Journal (United States)
Issue number1
Publication statusPublished - 1994


  • alcohol consumption
  • epidemiology
  • laryngeal cancer
  • laryngeal precancerous lesion
  • prevention
  • risk factors
  • tobacco smoke

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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