Effects of dantrolene sodium on GABAergic activity in spinal cord, corpus striatum, substantia nigra and cerebral cortex in rat

F. Patti, C. Maccagnano, A. M. Panico

Research output: Contribution to journalArticlepeer-review

Abstract

Dantrolene sodium has a muscle-relaxing effect ascribed to a peripheral action of the drug. Whether or not it has in addition a central effect is unsettled. GAD activity and GABA content were assayed in various areas of the central nervous system to clarify this possibility. From the results it may be assumed that dantrolene has a marked effect on central GABAergic tone, which could possibly explain both the therapeutic effects and the side-effects of the drug. A clinical review of the pharmacokinetics and pharmacodynamics of dantrolene is necessary, above all to furnish new clinical applications of the drug.

Original languageEnglish
Pages (from-to)384-388
Number of pages5
JournalActa Neurologica
Volume36
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Clinical Neurology

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