Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism

R. Libè, L. Barbetta, C. Dall'Asta, F. Salvaggio, C. Gala, P. Beck-Peccoz, Bruno Ambrosi

Research output: Contribution to journalArticlepeer-review

Abstract

Oral DHEA administration to patients with hypoadrenalism, in addition to glucocorticoid and mineralcorticoid replacement, may improve both well-being and hormonal/metabolic parameters. Twenty patients (13 men, 7 women, 26-76 yr, 11 with Addison's disease, 9 with central hypoadrenalism) were recruited in a placebo-controlled, randomized study. Hormone levels, carbohydrate and lipid parameters, bone metabolism, body composition and psychological parameters were evaluated at baseline and after treatment with DHEA 50 mg/day or placebo for 4 months. After 4 months of DHEA administration, serum DHEAS levels raised both in men (from 0.71±0.18 to 8.28±1.66 μmol/l, p

Original languageEnglish
Pages (from-to)736-741
Number of pages6
JournalJournal of Endocrinological Investigation
Volume27
Issue number8
Publication statusPublished - Sep 2004

Keywords

  • Addison's disease
  • Androgens
  • DHEA
  • Hypoadrenalism

ASJC Scopus subject areas

  • Endocrinology

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