Effects of denzimol on benzodiazepine receptors in the CNS: Relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat

Tiziana Mennini, Marco Gobbi, Rodolfo Testa

Research output: Contribution to journalArticlepeer-review

Abstract

Denzimol, a new anticonvulsant drug with a pharmacological profile similar to that of phenytoin, enhances the ataxic and antimetrazol activity of diazepam in rats without affecting its activity against picrotoxin-induced seizures. In vivo and ex vivo denzimol enhances the binding of 3H-flunitrazepam in cortex and in hippocampus but not in cerebellum. The possibility of this increase in the number of benzodiazepine binding sites contributing in some way to enhancement of the depressive and anticonvulsant activity of diazepam is discussed.

Original languageEnglish
Pages (from-to)1811-1820
Number of pages10
JournalLife Sciences
Volume35
Issue number18
DOIs
Publication statusPublished - Oct 29 1984

ASJC Scopus subject areas

  • Pharmacology

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