Effects of dietary resveratrol on the sleep-wake cycle in the non-human primate gray mouse lemur (microcebus murinus)

F. Pifferi, A. Rahman, S. Languille, A. Auffret, C. Babiloni, O. Blin, Y. Lamberty, J. C. Richardson, F. Aujard

Research output: Contribution to journalArticlepeer-review

Abstract

Converging evidence shows that the non-human primate gray mouse lemur (Microcebus murinus) is ideal for the study of the aging process and for testing the effects of new therapies and dietary interventions on age-associated pathologies. One such dietary supplement is resveratrol (RSV), a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. However, little is known about the effect of RSV on the lemur sleep-wake cycle, which reflects mammalian brain function and health. In the present study, the authors investigated this effect by comparing sleep-wake cycles in adult lemurs based on electroencephalographic (EEG) rhythms. The effect of short-term RSV supplementation on the sleep-wake cycle of mouse lemurs was evaluated in entrained conditions (long-day photoperiods, light:dark 14:10). After 3 wks of RSV supplementation, the animals exhibited a significantly increased proportion of active-wake time, occurring mainly during the resting phase of the sleep-wake cycle (+163%). The increase in active-wake time with RSV supplementation was accompanied by a significant reduction of both paradoxical sleep (-95%) and slow-wave sleep (-38%). These changes mainly occurred during the resting phase of the sleep-wake cycle (RSV supplementation induced negligible changes in active-wake time during the active phase of the sleep-wake cycle). The present data suggest that RSV may be a potent regulator of sleep-wake rhythms and could be of major interest in the study of sleep perturbations associated with aging and neuropathology.

Original languageEnglish
Pages (from-to)261-270
Number of pages10
JournalChronobiology International
Volume29
Issue number3
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Circadian rhythms
  • Electroencephalography
  • Metabolism
  • Microcebus murinus
  • Resveratrol
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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