Effects of dietary resveratrol on the sleep-wake cycle in the non-human primate gray mouse lemur (microcebus murinus)

F. Pifferi, A. Rahman, S. Languille, A. Auffret, C. Babiloni, O. Blin, Y. Lamberty, J. C. Richardson, F. Aujard

Research output: Contribution to journalArticle

Abstract

Converging evidence shows that the non-human primate gray mouse lemur (Microcebus murinus) is ideal for the study of the aging process and for testing the effects of new therapies and dietary interventions on age-associated pathologies. One such dietary supplement is resveratrol (RSV), a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. However, little is known about the effect of RSV on the lemur sleep-wake cycle, which reflects mammalian brain function and health. In the present study, the authors investigated this effect by comparing sleep-wake cycles in adult lemurs based on electroencephalographic (EEG) rhythms. The effect of short-term RSV supplementation on the sleep-wake cycle of mouse lemurs was evaluated in entrained conditions (long-day photoperiods, light:dark 14:10). After 3 wks of RSV supplementation, the animals exhibited a significantly increased proportion of active-wake time, occurring mainly during the resting phase of the sleep-wake cycle (+163%). The increase in active-wake time with RSV supplementation was accompanied by a significant reduction of both paradoxical sleep (-95%) and slow-wave sleep (-38%). These changes mainly occurred during the resting phase of the sleep-wake cycle (RSV supplementation induced negligible changes in active-wake time during the active phase of the sleep-wake cycle). The present data suggest that RSV may be a potent regulator of sleep-wake rhythms and could be of major interest in the study of sleep perturbations associated with aging and neuropathology.

Original languageEnglish
Pages (from-to)261-270
Number of pages10
JournalChronobiology International
Volume29
Issue number3
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Circadian rhythms
  • Electroencephalography
  • Metabolism
  • Microcebus murinus
  • Resveratrol
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Effects of dietary resveratrol on the sleep-wake cycle in the non-human primate gray mouse lemur (microcebus murinus)'. Together they form a unique fingerprint.

  • Cite this

    Pifferi, F., Rahman, A., Languille, S., Auffret, A., Babiloni, C., Blin, O., Lamberty, Y., Richardson, J. C., & Aujard, F. (2012). Effects of dietary resveratrol on the sleep-wake cycle in the non-human primate gray mouse lemur (microcebus murinus). Chronobiology International, 29(3), 261-270. https://doi.org/10.3109/07420528.2011.654019