TY - JOUR
T1 - Effects of different amounts of LH on superovulation induction with long-acting CnRH in an IVF program
AU - Ragni, Guido
AU - De Laurentis, Luciana
AU - Perotti, Laura
AU - Serra, Alessandra Dalla
AU - Vegetti, Walter
AU - Crosignani, Pier Giorgio
PY - 1996
Y1 - 1996
N2 - Objective-To evaluate whether different doses of exogenous LH affect IVF outcome. Design-Retrospective analysis of two consecutive trials. Setting-Infertility Unit of 1st Department of Obstetrics and Gynecology, University of Milan, Italy. Patients-Two groups of 40 eumennorrheic patients matched for age and indications for in vitro fertilization. Intervention-After suppression with a GnRH analogue, both groups received equal amounts of FSH in the first five days of stimulation; after this, the proportions of LH administered were doubled in one group because a different preparation was in use. Main outcome measures-The following observations were compared: number of scans (days to hCG), number of oocytes retrieved, fertilization rate, quality and number of embryos transferred, pregnancy and abortion rate. Results-Doubling the amount of LH administered does not affect any outcome measure except the number of days of stimulation needed prior to hCG administration. Conclusions-No significant difference was seen in terms of number of oocytes, embryo number and quality, pregnancy and abortion rate. The only differ-ence was the length of the stimulation phase.
AB - Objective-To evaluate whether different doses of exogenous LH affect IVF outcome. Design-Retrospective analysis of two consecutive trials. Setting-Infertility Unit of 1st Department of Obstetrics and Gynecology, University of Milan, Italy. Patients-Two groups of 40 eumennorrheic patients matched for age and indications for in vitro fertilization. Intervention-After suppression with a GnRH analogue, both groups received equal amounts of FSH in the first five days of stimulation; after this, the proportions of LH administered were doubled in one group because a different preparation was in use. Main outcome measures-The following observations were compared: number of scans (days to hCG), number of oocytes retrieved, fertilization rate, quality and number of embryos transferred, pregnancy and abortion rate. Results-Doubling the amount of LH administered does not affect any outcome measure except the number of days of stimulation needed prior to hCG administration. Conclusions-No significant difference was seen in terms of number of oocytes, embryo number and quality, pregnancy and abortion rate. The only differ-ence was the length of the stimulation phase.
KW - Abortion rate
KW - Amounts
KW - IVF, LH
KW - Pregnancy rate
KW - Superovulation
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M3 - Article
C2 - 8934255
AN - SCOPUS:0029831819
VL - 41
SP - 466
EP - 469
JO - International Journal of Fertility and Menopausal Studies
JF - International Journal of Fertility and Menopausal Studies
SN - 1069-3130
IS - 5
ER -