Effects of different amounts of LH on superovulation induction with long-acting CnRH in an IVF program

Guido Ragni, Luciana De Laurentis, Laura Perotti, Alessandra Dalla Serra, Walter Vegetti, Pier Giorgio Crosignani

Research output: Contribution to journalArticlepeer-review


Objective-To evaluate whether different doses of exogenous LH affect IVF outcome. Design-Retrospective analysis of two consecutive trials. Setting-Infertility Unit of 1st Department of Obstetrics and Gynecology, University of Milan, Italy. Patients-Two groups of 40 eumennorrheic patients matched for age and indications for in vitro fertilization. Intervention-After suppression with a GnRH analogue, both groups received equal amounts of FSH in the first five days of stimulation; after this, the proportions of LH administered were doubled in one group because a different preparation was in use. Main outcome measures-The following observations were compared: number of scans (days to hCG), number of oocytes retrieved, fertilization rate, quality and number of embryos transferred, pregnancy and abortion rate. Results-Doubling the amount of LH administered does not affect any outcome measure except the number of days of stimulation needed prior to hCG administration. Conclusions-No significant difference was seen in terms of number of oocytes, embryo number and quality, pregnancy and abortion rate. The only differ-ence was the length of the stimulation phase.

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalInternational Journal of Fertility and Menopausal Studies
Issue number5
Publication statusPublished - 1996


  • Abortion rate
  • Amounts
  • IVF, LH
  • Pregnancy rate
  • Superovulation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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