Effects of different doses of apomorphine on GAD activity in rat substantia nigra

D. F. Condorelli, G. Giammona, F. Patti, F. Nicoletti, L. Rampello, A. Reggio, M. Matera, R. M. Di Giorgio

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of different doses of the dopamine (DA) receptor agonist apomorphine on the activity of the γ-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) were investigated in rat substantia nigra in comparison with haloperidol and sulpiride, two DA receptor blocking agents. Results obtained show that low doses (10,35 μg/kg, s.c.) of apomorphine induce a decrease in nigral GAD activity whilst an opposite effect is observed with the highest dose (1000 μg/kg, s.c.). No significant change is observed following injection of the intermediate doses (100 and 500 μg/kg, s.c.). Moreover, sulpiride at the dose used (2 mg/kg, i.p.) induces an increase in GAD activity whilst no effect follows systemic injection of the same dose of haloperidol. The results are discussed in light of recent neurochemical and behavioral data.

Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalItalian Journal of Neurological Sciences
Volume2
Issue number3
DOIs
Publication statusPublished - Oct 1981

Keywords

  • Apomorphine
  • GAD
  • haloperidol
  • substantia nigra
  • sulpiride

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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