Effects of different peritoneal dialysis fluids on the Th1/Th2 balance

Carmelo Libetta, Pasquale Esposito, Vincenzo Sepe, Carlo Guastoni, Manuela Zucchi, Federica Meloni, Antonio dal Canton

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Peritoneal dialysis (PD) is associated with a depression of T cell function, as suggested by the impaired production of cytokines by Th cells collected from PD patients. Although treatment biocompatibility could be implicated in this immune dysfunction, it has been poorly investigated, thus far. Therefore, we undertook a study aiming to analyze the effects of different peritoneal dialysis fluids on the Th1/Th2 balance in PD patients. Methods. Twenty three patients on continuousambulatory peritoneal dialysis (CAPD) were evaluated. Seven patients were on CAPD with icodextrin solution (ICO-PD), seven with glucose and lactate/bicarbonate-buffered solution (LAC/BIC-PD), and nine with glucose and lactate-buffered solution (LAC-PD). The Th1/Th2 balance was evaluated by measuring IFN-γ(Th1 subset) and IL-4 (Th2 subset), both in circulating and peritoneum-derived Th lymphocytes unstimulated or stimulated by phytohemoagglutinin (PHA). Moreover inflammatory, nutritional and dialysis-related parameters were recorded. Eight normal subjects comprised the control group (CON). Results. Circulating T cells: IFN-γ was significantly lower in the LAC-PD group (p

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalEuropean Cytokine Network
Volume22
Issue number1
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Biocompatibility
  • Icodextrin
  • Peritoneal dialysis
  • Peritoneal fluids
  • Th1/Th2 imbalance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Biochemistry

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