Effects of different prostaglandins on glucose kinetics in the rat

L. Sacca, G. Perez, F. Rengo, M. Condorelli

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Abstract

The primed constant infusion of glucose 2 3H was used to study the influence of prostaglandin (PG) infusion (2 μg/min) on glucose turnover in intact rats in the postabsorptive state. While PGA1 did not exert any appreciable effect on glucose production by the liver and on plasma glucose levels, prostaglandins of E series significantly increased hepatic glucose output and consequently plasma glucose levels. In this regard, PGE1 appeared more effective than PGE2. In some experiments PGE1 was infused for 2 hr at the dose of 1.5 μg/min; glucose concentration rose to a maximum of 127% above the control values and glucose production reached during the 2nd hr of the infusion a level twice the base line (from 8.1 ± 0.5 to 16.9 ± 0.5 mg/kg body weight/min). These changes were paralleled by a proportional increase in glucose uptake by peripheral tissues which reached a level very near to that of hepatic output toward the end of the infusion.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalDiabetes
Volume23
Issue number6
Publication statusPublished - 1974

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Sacca, L., Perez, G., Rengo, F., & Condorelli, M. (1974). Effects of different prostaglandins on glucose kinetics in the rat. Diabetes, 23(6), 532-535.