The primed constant infusion of glucose 2 3H was used to study the influence of prostaglandin (PG) infusion (2 μg/min) on glucose turnover in intact rats in the postabsorptive state. While PGA1 did not exert any appreciable effect on glucose production by the liver and on plasma glucose levels, prostaglandins of E series significantly increased hepatic glucose output and consequently plasma glucose levels. In this regard, PGE1 appeared more effective than PGE2. In some experiments PGE1 was infused for 2 hr at the dose of 1.5 μg/min; glucose concentration rose to a maximum of 127% above the control values and glucose production reached during the 2nd hr of the infusion a level twice the base line (from 8.1 ± 0.5 to 16.9 ± 0.5 mg/kg body weight/min). These changes were paralleled by a proportional increase in glucose uptake by peripheral tissues which reached a level very near to that of hepatic output toward the end of the infusion.
|Number of pages||4|
|Publication status||Published - 1974|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine