Effects of different prostaglandins on glucose kinetics in the rat

L. Sacca, G. Perez, F. Rengo, M. Condorelli

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The primed constant infusion of glucose 2 3H was used to study the influence of prostaglandin (PG) infusion (2 μg/min) on glucose turnover in intact rats in the postabsorptive state. While PGA1 did not exert any appreciable effect on glucose production by the liver and on plasma glucose levels, prostaglandins of E series significantly increased hepatic glucose output and consequently plasma glucose levels. In this regard, PGE1 appeared more effective than PGE2. In some experiments PGE1 was infused for 2 hr at the dose of 1.5 μg/min; glucose concentration rose to a maximum of 127% above the control values and glucose production reached during the 2nd hr of the infusion a level twice the base line (from 8.1 ± 0.5 to 16.9 ± 0.5 mg/kg body weight/min). These changes were paralleled by a proportional increase in glucose uptake by peripheral tissues which reached a level very near to that of hepatic output toward the end of the infusion.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalDiabetes
Volume23
Issue number6
Publication statusPublished - 1974

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Prostaglandins
Glucose
Alprostadil
Liver
Prostaglandins E
Dinoprostone
Body Weight

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Sacca, L., Perez, G., Rengo, F., & Condorelli, M. (1974). Effects of different prostaglandins on glucose kinetics in the rat. Diabetes, 23(6), 532-535.

Effects of different prostaglandins on glucose kinetics in the rat. / Sacca, L.; Perez, G.; Rengo, F.; Condorelli, M.

In: Diabetes, Vol. 23, No. 6, 1974, p. 532-535.

Research output: Contribution to journalArticle

Sacca, L, Perez, G, Rengo, F & Condorelli, M 1974, 'Effects of different prostaglandins on glucose kinetics in the rat', Diabetes, vol. 23, no. 6, pp. 532-535.
Sacca L, Perez G, Rengo F, Condorelli M. Effects of different prostaglandins on glucose kinetics in the rat. Diabetes. 1974;23(6):532-535.
Sacca, L. ; Perez, G. ; Rengo, F. ; Condorelli, M. / Effects of different prostaglandins on glucose kinetics in the rat. In: Diabetes. 1974 ; Vol. 23, No. 6. pp. 532-535.
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