Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat

G. Cavaletti, G. Tredici, M. G. Petruccioli, E. Dondè, P. Tredici, P. Marmiroli, C. Minoia, A. Ronchi, M. Bayssas, G. Griffon Etienne

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to determine the influence of oxaliplatin scheduling on the onset of peripheral neurotoxicity and ototoxicity in a rat model. Animals were treated with four different schedules of oxaliplatin using two cumulative doses (36 and 48 mg/kg intraperitoneally (i.p.)). The neuropathological examination evidenced dorsal root ganglia (DRG) nucleolar, nuclear and somatic size reduction with nucleolar segregation in the treated rats. Sensory nerve conduction velocity (SNCV) was reduced after oxaliplatin treatment, while the auditory pathway was unaffected. After treatment, platinum was detected in the kidney, DRG and sciatic nerve. After a 5-week follow-up period, recovery of the pathological changes in the DRG and sciatic nerves occurred, although platinum was still detectable in these tissues. The following conclusions may be drawn: the main targets of oxaliplatin neurotoxicity were the DRG; the shorter the interval between the injections, the higher the severity of peripheral neuropathy and this was also related to the cumulative oxaliplatin dose; the peripheral neurotoxicity tended to be reversible; ototoxicity was absent even with high cumulative doses of oxaliplatin.

Original languageEnglish
Pages (from-to)2457-2463
Number of pages7
JournalEuropean Journal of Cancer
Volume37
Issue number18
DOIs
Publication statusPublished - 2001

Keywords

  • Audiometry
  • Neuropathy
  • Oxaliplatin
  • Rat
  • Toxicity

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat'. Together they form a unique fingerprint.

Cite this