Effects of different ventilator settings on sleep and inspiratory effort in patients with neuromuscular disease

Francesco Fanfulla, Monica Delmastro, Angela Berardinelli, Nadia D Artavilla Lupo, Stefano Nava

Research output: Contribution to journalArticlepeer-review


Patients with neuromuscular disease (NMD) who require long-term ventilation normally have the ventilation set using empirical day-time parameters. We evaluated arterial blood gases (ABG), breathing pattern, respiratory muscle function, and sleep architecture during ventilation with two noninvasive Pressure Support Ventilation (nPSV) settings in nine patients with NMD. The two settings were randomly applied: the usual (US), with the nPSV setting titrated on simple clinical parameters, and the physiological (PHYS), tailored to the patient's respiratory effort. During wakefulness, nPSV significantly improved ABG and minute ventilation and reduced the diaphragmatic pressure-time product (PTPdi/breath), independently of the type of setting (PTPdi/breath spontaneous breathing 5.7 ± 2.4, US 3.2 ± 2, PHYS 3.6 ± 1.6 cm H 2O · seconds -1, p <0.001). However, during sleep, PHY nPSV resulted in a significant improvement of gas exchange, sleep efficiency (71.7% ± 14 US vs. 80.6% ± 8.3 PHYS, p <0.01) and % of REM sleep (9.1% ± 7 US vs. 17.3% ± 5.4 PHYS, p <0.01). This improvement was significantly correlated with the reduction in ineffective efforts. In NMD, nPSV is effective in improving daytime ABG and in unloading inspiratory muscles independently of whether it is set on the basis of the patient's comfort or the patient's respiratory mechanics. However, PHYS was associated with better sleep architecture and nighttime gas exchange.

Original languageEnglish
Pages (from-to)619-624
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number5
Publication statusPublished - Sep 1 2005


  • Home care
  • Noninvasive mechanical ventilation
  • Polysomnography
  • Respiratory failure
  • Sleep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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