Effects of dilazep on human platelets and rat vascular tissue: In vitro studies on platelet aggregation, and arachidonic acid oxidation

S. Colli, P. Maderna, G. Morazzoni, C. Speroni, E. Tremoli

Research output: Contribution to journalArticle

Abstract

The "in vitro" effects of Dilazep on platelet aggregation and arachidonic acid oxidation in platelets and vessel wall were studied. Dilazep exerted a clearcut inhibitory effect on platelet aggregation induced by several stimuli. In addition, the compound completely suppressed malondialdehyde production by platelets elicited by collagen and thrombin, in a dose-dependent fashion. The evaluation of Dilazep effects on the in vitro release of prostacyclin-like material by rat aortic tissue did not provide any indication about an interference of the drug on the generation of endogenous antiaggregatory material.

Original languageEnglish
Pages (from-to)593-602
Number of pages10
JournalPharmacological Research Communications
Volume15
Issue number6
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pharmacology

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