Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina: Implications for mechanism of action

S. de Servi; M. Ferrario; S. Ghio; A. Bartoli; A. Mussini; E. Poma; L. Angoli; E. Bramucci; E. Aimè; R. Rondanelli

Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina: Implications for mechanism of action

S. de Servi, M. Ferrario, S. Ghio, A. Bartoli, A. Mussini, E. Poma, L. Angoli, E. Bramucci, E. Aimè, R. Rondanelli

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate the mechanism of the antianginal action of diltiazem in stress-induced myocardial ischemia, we studied 12 patients with stable exertional angina and disease of the proximal left anterior descending artery by measuring great cardiac vein flow (GVCF) and calculating anterior regional coronary resistance (ARCR) during myocardial ischemia induced by atrial pacing before and after intravenous administration of diltiazem (0.25 mg/kg in a bolus dose followed by continuous infusion of 0.005 mg/kg/min). Diltiazem increased the pacing time to angina from 6.9 ± 3.5 to 10.7 ± 4 min (p

Original language	English
Pages (from-to)	1248-1253
Number of pages	6
Journal	Circulation
Volume	73
Issue number	6
Publication status	Published - 1986

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

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title = "Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina: Implications for mechanism of action",

abstract = "To investigate the mechanism of the antianginal action of diltiazem in stress-induced myocardial ischemia, we studied 12 patients with stable exertional angina and disease of the proximal left anterior descending artery by measuring great cardiac vein flow (GVCF) and calculating anterior regional coronary resistance (ARCR) during myocardial ischemia induced by atrial pacing before and after intravenous administration of diltiazem (0.25 mg/kg in a bolus dose followed by continuous infusion of 0.005 mg/kg/min). Diltiazem increased the pacing time to angina from 6.9 ± 3.5 to 10.7 ± 4 min (p",

author = "{de Servi}, S. and M. Ferrario and S. Ghio and A. Bartoli and A. Mussini and E. Poma and L. Angoli and E. Bramucci and E. Aim{\`e} and R. Rondanelli",

year = "1986",

language = "English",

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T1 - Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina

T2 - Implications for mechanism of action

AU - de Servi, S.

AU - Ferrario, M.

AU - Ghio, S.

AU - Bartoli, A.

AU - Mussini, A.

AU - Poma, E.

AU - Angoli, L.

AU - Bramucci, E.

AU - Aimè, E.

AU - Rondanelli, R.

PY - 1986

Y1 - 1986

N2 - To investigate the mechanism of the antianginal action of diltiazem in stress-induced myocardial ischemia, we studied 12 patients with stable exertional angina and disease of the proximal left anterior descending artery by measuring great cardiac vein flow (GVCF) and calculating anterior regional coronary resistance (ARCR) during myocardial ischemia induced by atrial pacing before and after intravenous administration of diltiazem (0.25 mg/kg in a bolus dose followed by continuous infusion of 0.005 mg/kg/min). Diltiazem increased the pacing time to angina from 6.9 ± 3.5 to 10.7 ± 4 min (p

AB - To investigate the mechanism of the antianginal action of diltiazem in stress-induced myocardial ischemia, we studied 12 patients with stable exertional angina and disease of the proximal left anterior descending artery by measuring great cardiac vein flow (GVCF) and calculating anterior regional coronary resistance (ARCR) during myocardial ischemia induced by atrial pacing before and after intravenous administration of diltiazem (0.25 mg/kg in a bolus dose followed by continuous infusion of 0.005 mg/kg/min). Diltiazem increased the pacing time to angina from 6.9 ± 3.5 to 10.7 ± 4 min (p

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Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina: Implications for mechanism of action

Abstract

ASJC Scopus subject areas

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