Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina: Implications for mechanism of action

S. de Servi, M. Ferrario, S. Ghio, A. Bartoli, A. Mussini, E. Poma, L. Angoli, E. Bramucci, E. Aimè, R. Rondanelli

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the mechanism of the antianginal action of diltiazem in stress-induced myocardial ischemia, we studied 12 patients with stable exertional angina and disease of the proximal left anterior descending artery by measuring great cardiac vein flow (GVCF) and calculating anterior regional coronary resistance (ARCR) during myocardial ischemia induced by atrial pacing before and after intravenous administration of diltiazem (0.25 mg/kg in a bolus dose followed by continuous infusion of 0.005 mg/kg/min). Diltiazem increased the pacing time to angina from 6.9 ± 3.5 to 10.7 ± 4 min (p

Original languageEnglish
Pages (from-to)1248-1253
Number of pages6
JournalCirculation
Volume73
Issue number6
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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