Effects of dimethylformamide (dmf) on coagulation and platelet activity

Marcello Imbriani, Sergio Ghittori, Alberto Prestinoni, Patrizia Longoni, Giorgio Cascone, Gabriella Gamba

Research output: Contribution to journalArticle

Abstract

The effects of dimethylformamide (DMF) on hemostatic functions, especially on platelet activity, were examined both in vitro and in vivo in 15 workers exposed to DMF (27 mg/m3, median value). Twenty-eight control subjects who were not exposed to DMF, but comparable for age, anthropometric data, and smoking habits, were also studied. Workers exposed to DMF showed a decrease in the number of platelets and had longer coagulation times, probably due to a change caused by DMF on the membrane receptor of platelets and on the phospholipid components of the clotting system.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalArchives of Environmental Health
Volume41
Issue number2
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

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