Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig

N. Berretta, F. Berton, R. Bianchi, M. Capogna, W. Francesconi, M. Brunelli

Research output: Contribution to journalArticle

Abstract

In hippocampal pyramidal cells (HPCs), Dopamine (DA) application (1 μM) produced, in 50% of recorded cells, an hyperpolarization of the resting membrane potential (r.m.p.) and an increase of the afterhyperpolarization (AHP) amplitude and duration in 79% of recorded cells. DA-induced effects on both the r.m.p. and AHP were mimicked by bath application of a D-l selective agonist, SKF 38393 (20 μM). In addition, we have observed that a D-l selective antagonist such as SCH 23390 (1 μ,M) abolished the action of both DA and SKF 38393. In contrast, the activation of D-2 receptors through LY 171555 (10 μm) produced, in 50% of cells, a depolarization of the r.m.p. and a depression of the AHP in 67% of recorded cells. These results suggest that the effects observed in hippocampal pyramidal neurons after DA application of micromolar concentration are mediated by D-1 subtype of receptors.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalExperimental Brain Research
Volume83
Issue number1
DOIs
Publication statusPublished - Dec 1990

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Keywords

  • Afterhyperpolarization
  • D-1 and D-2 agonists
  • Dopamine
  • Guinea pig
  • Hippocampal slices

ASJC Scopus subject areas

  • Neuroscience(all)

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