Effects of dopaminergic drugs on cerebellar prostaglandin concentrations

C. Millia, F. Nicoletti, A. A. Grasso, F. Patti, D. F. Condorelli, E. Rapisarda, L. Rampello, G. Costa, U. Scapagnini

Research output: Contribution to journalArticlepeer-review

Abstract

Previous data indicate that the injection of dopaminergic drugs induces changes in cerebellar 3',5'-guanosine monophosphate (cGMP) content. Accordingly, we have investigated the effects of haloperidol, sulpiride, or apomorphine on cerebellar prostaglandin (PG) concentration, a parameter related to cGMP content. Results obtained show that dopamine receptor blocking agents, such as haloperidol and sulpiride, significantly decrease cerebellar PGE2 and PGF(2α) concentrations, while opposite changes are induced by apomorphine, a dopamine receptor agonist

Original languageEnglish
Pages (from-to)1190-1191
Number of pages2
JournalJournal of Neurochemistry
Volume41
Issue number4
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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