Effects of dopaminergic stimulation on peripheral markers of apoptosis: Relevance to Parkinson's disease

F. Blandini, A. Mangiagalli, E. Martignoni, A. Samuele, R. Fancellu, C. Tassorelli, M. Cosentino, F. Marino, E. Rasini, D. Calandrella, G. Riboldazzi, C. Colombo, G. M. Frigo, G. Nappi

Research output: Contribution to journalArticle

Abstract

We investigated the effects of dopaminergic stimulation on anti-apoptotic protein Bcl-2, pro-apoptotic enzyme caspase-3, and anti-oxidant/anti-apoptotic enzyme Cu/Zn super-oxide dismutase (SOD) in human lymphocytes exposed to dopamine (DA). The same determinations were also carried out in parkinsonian patients treated with L-dopa. Caspase-3 activity and Cu/Zn SOD levels tended to increase when lymphocytes were exposed to low or intermediate doses of DA, while a decrease was observed, particularly in caspase-3 activity, with the higher DA dose. Bcl-2 levels were unaffected. In patients, we observed a negative correlation between Cu/Zn SOD levels and daily intake of L-dopa, which also tended to be negatively correlated with caspase-3 activity, but not with Bcl-2. Our results show that dopaminergic stimulation is associated with complex changes in regulatory proteins of apoptosis.

Original languageEnglish
Pages (from-to)157-158
Number of pages2
JournalNeurological Sciences
Volume24
Issue number3
DOIs
Publication statusPublished - Oct 2003

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Blandini, F., Mangiagalli, A., Martignoni, E., Samuele, A., Fancellu, R., Tassorelli, C., Cosentino, M., Marino, F., Rasini, E., Calandrella, D., Riboldazzi, G., Colombo, C., Frigo, G. M., & Nappi, G. (2003). Effects of dopaminergic stimulation on peripheral markers of apoptosis: Relevance to Parkinson's disease. Neurological Sciences, 24(3), 157-158. https://doi.org/10.1007/s10072-003-0107-1