Effects of dothiepin on nociceptive flexion reflex and diffuse noxious inhibitory controls in humans

Giorgio Sandrini, Luigi Ruiz, Michele Capararo, Andrei Danilov, Achille Beretta, Guiseppe Nappi

Research output: Contribution to journalArticle

Abstract

The analgesic activity of dothiepin (an antidepressant interacting with serotonin receptors) was studied (double-blind) in humans. A significant increase in nociceptive flexion reflex threshold and subjective pain threshold was observed after a 14-day dothiepin treatment. The effects of dothiepin on diffuse noxious inhibitory controls were also investigated using the cold-pressor test as conditioning stimuli. After dothiepin a reduced inhibition of nociceptive flexion reflex during the cold-pressor test and a significant facilitation immediately after the cold-pressor test were observed, while the subjective pain perception was normally inhibited. Our data suggest a serotonergic modulation of diffuse noxious inhibitory controls in humans.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalEuropean Journal of Pharmacology
Volume243
Issue number1
DOIs
Publication statusPublished - Oct 12 1993

Keywords

  • (Human)
  • Cold-pressor test
  • Diffuse noxious inhibitory controls
  • Dothiepin
  • Nociceptive flexion reflex

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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