Effects of dynorphin on the pha-induced lymphocyte proliferation in vitro

T. Barreca, G. Di Benedetto, G. Corsini, G. Lenzi, F. Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the opioid peptide dynorphin (DYN) on PHA-induced lymphocyte proliferation has been evaluated in the present study. A significant increase in PHA-induced lymphocyte activation was observed when DYN was added to cultures 48 hr after the mitogenic stimulation. This effect occurred at suboptimal (3.12 and 6.25 ug/ml) PHA concentrations and at DYN doses ranging from 10-9 to 10-12 M. Conversely, DYN did not affect the lymphocyte blastogenic process either when added before, or simultaneously or after intense PHA (12.5 ug/ml) stimulation. Naloxone preincubation did not modify the above described effects. Results suggest that DYN might play a role in neuroendocrine regulation of the lymphocyte blastogenic process.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Volume9
Issue number4
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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