Effects of Early Nutrition on the Infant Metabolome

Christian Hellmuth, Olaf Uhl, Franca F. Kirchberg, Veit Grote, Martina Weber, Peter Rzehak, Clotilde Carlier, Natalia Ferre, Elvira Verduci, Dariusz Gruszfeld, Piotr Socha, Philippe Goyens, Pascale Poncelet, Elena Dain, Joana Hoyos, Françoise Martin, Annick Xhonneux, Jean Paul Langhendries, Jean Noel Van Hees, Ricardo Closa-MonasteroloJoaquin Escribano, Veronica Luque, Georgina Mendez, Marta Zaragoza-Jordana, Marcello Giovannini, Enrica Riva, Carlo Agostoni, Silvia Scaglioni, Fiammetta Vecchi, Alice Re Dionigi, Jerzy Socha, Anna Dobrzanska, Anna Stolarczyk, Agnieszka Kowalik, Roman Janas, Ewa Pietraszek, Emmanuel Perrin, Helfried Groebe, Anna Reith, Renate Hofmann, Berthold Koletzko, Sonia Schiess, Jeannette Beyer, Michaela Fritsch, Uschi Handel, Ingrid Pawellek, Sabine Verwied-Jorky, Iris Hannibal, Hans Demmelmair, Gudrun Haile, Wolfgang Peissner, Ulrike Harder, Melissa Theurich, Rüdiger Von Kries

Research output: Contribution to journalArticle

Abstract

Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalNestle Nutrition Institute Workshop Series
Volume85
DOIs
Publication statusPublished - 2016

Fingerprint

metabolome
Metabolome
protein intake
breast feeding
oxidation
nutrition
insulin
bottle feeding
Proteins
branched chain amino acids
beta oxidation
childhood obesity
proteins
carnitine
somatomedins
adiposity
infant formulas
Breast Feeding
body fat
weight gain

ASJC Scopus subject areas

  • Food Science
  • Pediatrics, Perinatology, and Child Health
  • Nutrition and Dietetics

Cite this

Hellmuth, C., Uhl, O., Kirchberg, F. F., Grote, V., Weber, M., Rzehak, P., ... Von Kries, R. (2016). Effects of Early Nutrition on the Infant Metabolome. Nestle Nutrition Institute Workshop Series, 85, 89-100. https://doi.org/10.1159/000439491

Effects of Early Nutrition on the Infant Metabolome. / Hellmuth, Christian; Uhl, Olaf; Kirchberg, Franca F.; Grote, Veit; Weber, Martina; Rzehak, Peter; Carlier, Clotilde; Ferre, Natalia; Verduci, Elvira; Gruszfeld, Dariusz; Socha, Piotr; Goyens, Philippe; Poncelet, Pascale; Dain, Elena; Hoyos, Joana; Martin, Françoise; Xhonneux, Annick; Langhendries, Jean Paul; Van Hees, Jean Noel; Closa-Monasterolo, Ricardo; Escribano, Joaquin; Luque, Veronica; Mendez, Georgina; Zaragoza-Jordana, Marta; Giovannini, Marcello; Riva, Enrica; Agostoni, Carlo; Scaglioni, Silvia; Vecchi, Fiammetta; Re Dionigi, Alice; Socha, Jerzy; Dobrzanska, Anna; Stolarczyk, Anna; Kowalik, Agnieszka; Janas, Roman; Pietraszek, Ewa; Perrin, Emmanuel; Groebe, Helfried; Reith, Anna; Hofmann, Renate; Koletzko, Berthold; Schiess, Sonia; Beyer, Jeannette; Fritsch, Michaela; Handel, Uschi; Pawellek, Ingrid; Verwied-Jorky, Sabine; Hannibal, Iris; Demmelmair, Hans; Haile, Gudrun; Peissner, Wolfgang; Harder, Ulrike; Theurich, Melissa; Von Kries, Rüdiger.

In: Nestle Nutrition Institute Workshop Series, Vol. 85, 2016, p. 89-100.

Research output: Contribution to journalArticle

Hellmuth, C, Uhl, O, Kirchberg, FF, Grote, V, Weber, M, Rzehak, P, Carlier, C, Ferre, N, Verduci, E, Gruszfeld, D, Socha, P, Goyens, P, Poncelet, P, Dain, E, Hoyos, J, Martin, F, Xhonneux, A, Langhendries, JP, Van Hees, JN, Closa-Monasterolo, R, Escribano, J, Luque, V, Mendez, G, Zaragoza-Jordana, M, Giovannini, M, Riva, E, Agostoni, C, Scaglioni, S, Vecchi, F, Re Dionigi, A, Socha, J, Dobrzanska, A, Stolarczyk, A, Kowalik, A, Janas, R, Pietraszek, E, Perrin, E, Groebe, H, Reith, A, Hofmann, R, Koletzko, B, Schiess, S, Beyer, J, Fritsch, M, Handel, U, Pawellek, I, Verwied-Jorky, S, Hannibal, I, Demmelmair, H, Haile, G, Peissner, W, Harder, U, Theurich, M & Von Kries, R 2016, 'Effects of Early Nutrition on the Infant Metabolome', Nestle Nutrition Institute Workshop Series, vol. 85, pp. 89-100. https://doi.org/10.1159/000439491
Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P et al. Effects of Early Nutrition on the Infant Metabolome. Nestle Nutrition Institute Workshop Series. 2016;85:89-100. https://doi.org/10.1159/000439491
Hellmuth, Christian ; Uhl, Olaf ; Kirchberg, Franca F. ; Grote, Veit ; Weber, Martina ; Rzehak, Peter ; Carlier, Clotilde ; Ferre, Natalia ; Verduci, Elvira ; Gruszfeld, Dariusz ; Socha, Piotr ; Goyens, Philippe ; Poncelet, Pascale ; Dain, Elena ; Hoyos, Joana ; Martin, Françoise ; Xhonneux, Annick ; Langhendries, Jean Paul ; Van Hees, Jean Noel ; Closa-Monasterolo, Ricardo ; Escribano, Joaquin ; Luque, Veronica ; Mendez, Georgina ; Zaragoza-Jordana, Marta ; Giovannini, Marcello ; Riva, Enrica ; Agostoni, Carlo ; Scaglioni, Silvia ; Vecchi, Fiammetta ; Re Dionigi, Alice ; Socha, Jerzy ; Dobrzanska, Anna ; Stolarczyk, Anna ; Kowalik, Agnieszka ; Janas, Roman ; Pietraszek, Ewa ; Perrin, Emmanuel ; Groebe, Helfried ; Reith, Anna ; Hofmann, Renate ; Koletzko, Berthold ; Schiess, Sonia ; Beyer, Jeannette ; Fritsch, Michaela ; Handel, Uschi ; Pawellek, Ingrid ; Verwied-Jorky, Sabine ; Hannibal, Iris ; Demmelmair, Hans ; Haile, Gudrun ; Peissner, Wolfgang ; Harder, Ulrike ; Theurich, Melissa ; Von Kries, Rüdiger. / Effects of Early Nutrition on the Infant Metabolome. In: Nestle Nutrition Institute Workshop Series. 2016 ; Vol. 85. pp. 89-100.
@article{6bed7466133e4834bfca5bd0c2e292e6,
title = "Effects of Early Nutrition on the Infant Metabolome",
abstract = "Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.",
author = "Christian Hellmuth and Olaf Uhl and Kirchberg, {Franca F.} and Veit Grote and Martina Weber and Peter Rzehak and Clotilde Carlier and Natalia Ferre and Elvira Verduci and Dariusz Gruszfeld and Piotr Socha and Philippe Goyens and Pascale Poncelet and Elena Dain and Joana Hoyos and Fran{\cc}oise Martin and Annick Xhonneux and Langhendries, {Jean Paul} and {Van Hees}, {Jean Noel} and Ricardo Closa-Monasterolo and Joaquin Escribano and Veronica Luque and Georgina Mendez and Marta Zaragoza-Jordana and Marcello Giovannini and Enrica Riva and Carlo Agostoni and Silvia Scaglioni and Fiammetta Vecchi and {Re Dionigi}, Alice and Jerzy Socha and Anna Dobrzanska and Anna Stolarczyk and Agnieszka Kowalik and Roman Janas and Ewa Pietraszek and Emmanuel Perrin and Helfried Groebe and Anna Reith and Renate Hofmann and Berthold Koletzko and Sonia Schiess and Jeannette Beyer and Michaela Fritsch and Uschi Handel and Ingrid Pawellek and Sabine Verwied-Jorky and Iris Hannibal and Hans Demmelmair and Gudrun Haile and Wolfgang Peissner and Ulrike Harder and Melissa Theurich and {Von Kries}, R{\"u}diger",
year = "2016",
doi = "10.1159/000439491",
language = "English",
volume = "85",
pages = "89--100",
journal = "Nestle Nutrition Institute Workshop Series",
issn = "1664-2155",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Effects of Early Nutrition on the Infant Metabolome

AU - Hellmuth, Christian

AU - Uhl, Olaf

AU - Kirchberg, Franca F.

AU - Grote, Veit

AU - Weber, Martina

AU - Rzehak, Peter

AU - Carlier, Clotilde

AU - Ferre, Natalia

AU - Verduci, Elvira

AU - Gruszfeld, Dariusz

AU - Socha, Piotr

AU - Goyens, Philippe

AU - Poncelet, Pascale

AU - Dain, Elena

AU - Hoyos, Joana

AU - Martin, Françoise

AU - Xhonneux, Annick

AU - Langhendries, Jean Paul

AU - Van Hees, Jean Noel

AU - Closa-Monasterolo, Ricardo

AU - Escribano, Joaquin

AU - Luque, Veronica

AU - Mendez, Georgina

AU - Zaragoza-Jordana, Marta

AU - Giovannini, Marcello

AU - Riva, Enrica

AU - Agostoni, Carlo

AU - Scaglioni, Silvia

AU - Vecchi, Fiammetta

AU - Re Dionigi, Alice

AU - Socha, Jerzy

AU - Dobrzanska, Anna

AU - Stolarczyk, Anna

AU - Kowalik, Agnieszka

AU - Janas, Roman

AU - Pietraszek, Ewa

AU - Perrin, Emmanuel

AU - Groebe, Helfried

AU - Reith, Anna

AU - Hofmann, Renate

AU - Koletzko, Berthold

AU - Schiess, Sonia

AU - Beyer, Jeannette

AU - Fritsch, Michaela

AU - Handel, Uschi

AU - Pawellek, Ingrid

AU - Verwied-Jorky, Sabine

AU - Hannibal, Iris

AU - Demmelmair, Hans

AU - Haile, Gudrun

AU - Peissner, Wolfgang

AU - Harder, Ulrike

AU - Theurich, Melissa

AU - Von Kries, Rüdiger

PY - 2016

Y1 - 2016

N2 - Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.

AB - Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.

UR - http://www.scopus.com/inward/record.url?scp=84965082752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965082752&partnerID=8YFLogxK

U2 - 10.1159/000439491

DO - 10.1159/000439491

M3 - Article

AN - SCOPUS:84965082752

VL - 85

SP - 89

EP - 100

JO - Nestle Nutrition Institute Workshop Series

JF - Nestle Nutrition Institute Workshop Series

SN - 1664-2155

ER -