TY - JOUR
T1 - Effects of Efficiency and Length of Acetate-Free Biofiltration Session on Postdialysis Solute Rebound
AU - Giannattasio, Paolo
AU - Minutolo, Roberto
AU - Bellizzi, Vincenzo
AU - Di Iorio, Biagio R.
AU - Scigliano, Raffaele
AU - Zamboli, Pasquale
AU - Venditti, Guglielmo
AU - Manganelli, Rocco
AU - De Simone, Walter
AU - Aucella, Filippo
AU - Stallone, Carmine
AU - Spiezia, Stefano
AU - Conte, Giuseppe
AU - De Nicola, Luca
PY - 2006/6
Y1 - 2006/6
N2 - Background: Postdialytic rebound (PDR) of plasma solutes is a relevant drawback of intermittent hemodialysis, but its pathophysiological process remains undefined. We assessed the independent effects of efficiency and length of dialytic session on PDR of urea, phosphate, and potassium. Methods: Uremic patients were evaluated at the beginning and end of dialysis and after 180 minutes in 2 randomized crossover studies. In study 1, we compared the effect of standard versus higher efficiency acetate-free biofiltration (AFB) while maintaining the same duration of 4 hours. In study 2, we compared the effect of 3- versus 5-hour AFB sessions while maintaining similar efficiency. Results: In study 1, greater Kt/V (1.49 ± 0.20 versus 1.22 ± 0.15; P <0.0001) was coupled with significant increases in both absolute removal and PDR of urea and phosphate (PDR of urea, +45% versus +29%; PDR of phosphate, +79% versus +52%), but not of potassium. Similarly, in study 2, shortening the AFB session while maintaining similar absolute removal and Kt/V (1.28 ± 0.09 versus 1.31 ± 0.09) significantly increased PDR of urea and phosphate (PDR of urea, +32% versus +19%; PDR of phosphate, +63% versus +36%), but not of potassium. In both studies, greater PDRs of urea and phosphate were associated with estimated greater removal of these solutes per hour. Conclusion: The rate of removal of phosphate and urea is a critical determinant of their PDR; conversely, potassium is not influenced by removal rate, likely because of its marked cell compartmentalization.
AB - Background: Postdialytic rebound (PDR) of plasma solutes is a relevant drawback of intermittent hemodialysis, but its pathophysiological process remains undefined. We assessed the independent effects of efficiency and length of dialytic session on PDR of urea, phosphate, and potassium. Methods: Uremic patients were evaluated at the beginning and end of dialysis and after 180 minutes in 2 randomized crossover studies. In study 1, we compared the effect of standard versus higher efficiency acetate-free biofiltration (AFB) while maintaining the same duration of 4 hours. In study 2, we compared the effect of 3- versus 5-hour AFB sessions while maintaining similar efficiency. Results: In study 1, greater Kt/V (1.49 ± 0.20 versus 1.22 ± 0.15; P <0.0001) was coupled with significant increases in both absolute removal and PDR of urea and phosphate (PDR of urea, +45% versus +29%; PDR of phosphate, +79% versus +52%), but not of potassium. Similarly, in study 2, shortening the AFB session while maintaining similar absolute removal and Kt/V (1.28 ± 0.09 versus 1.31 ± 0.09) significantly increased PDR of urea and phosphate (PDR of urea, +32% versus +19%; PDR of phosphate, +63% versus +36%), but not of potassium. In both studies, greater PDRs of urea and phosphate were associated with estimated greater removal of these solutes per hour. Conclusion: The rate of removal of phosphate and urea is a critical determinant of their PDR; conversely, potassium is not influenced by removal rate, likely because of its marked cell compartmentalization.
KW - dialysis efficiency
KW - phosphate
KW - potassium
KW - Urea
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U2 - 10.1053/j.ajkd.2006.03.035
DO - 10.1053/j.ajkd.2006.03.035
M3 - Article
C2 - 16731300
AN - SCOPUS:33646857671
VL - 47
SP - 1045
EP - 1054
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 6
ER -