Abstract
The aim of the No Pain in Labour (NoPiL) study was evaluate the stress and clinical outcome of infants vaginally born without maternal analgesia and after maternal epidural or systemic analgesia. We studied 120 healthy term infants, 41 in the no analgesia group, 38 in the epidural analgesia group, and 41 in the systemic analgesia group. Cortisol, s-endorphin, oxidative stress markers [ie: total hydroperoxide (TH) and advanced oxidation protein products (AOPP)], interleukin-1β (IL-1β), and interleukin-8 (IL-8) cytokines were measured in arterial cord blood samples. Infants in the 3 groups had similar Apgar score, cord blood pH and occurrence of hypoglycaemia, hyperbilirubinemia, and respiratory depression. Cortisol and endorphin plasma levels did not differ in the groups, nor did TH and AOPP values. IL-1β and IL-8 cytokine were higher in infants born after maternal epidural analgesia than in other groups. Short-term outcome and stress were similar in infants vaginally born without maternal analgesia and after epidural and systemic analgesia. The possible implications of the highest interleukin levels in the epidural analgesia group deserve further study.
| Original language | English |
|---|---|
| Pages (from-to) | 1514-1519 |
| Number of pages | 6 |
| Journal | Frontiers in Bioscience - Elite |
| Volume | 2 E |
| Issue number | 4 |
| Publication status | Published - Jan 6 2010 |
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Keywords
- Epidural analgesia
- Interleukin
- Newborn
- Oxidative stress
- Stress
- Systemic analgesia
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)
Cite this
Effects of epidural and systemic maternal analgesia in term infants : The NoPiL study. / Dani, Carlo; Perugi, Silvia; Fontanelli, Giulia; Bertini, Giovanna; Pratesi, Simone; Buonocore, Giuseppe; Longini, Mariangela; Proietti, Fabrizio; Felici, Cosetta; Ciuti, Riccardo; D'Onofrio, Paola; Novelli, Annamaria Melani; Pezzati, Marco; Gambi, Davide; Scarselli, Gianfranco; Frigiola, Alessandro; Giamberti, Alessandro; Abella, Raul; Rubaltelli, Firmino F.
In: Frontiers in Bioscience - Elite, Vol. 2 E, No. 4, 06.01.2010, p. 1514-1519.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of epidural and systemic maternal analgesia in term infants
T2 - The NoPiL study
AU - Dani, Carlo
AU - Perugi, Silvia
AU - Fontanelli, Giulia
AU - Bertini, Giovanna
AU - Pratesi, Simone
AU - Buonocore, Giuseppe
AU - Longini, Mariangela
AU - Proietti, Fabrizio
AU - Felici, Cosetta
AU - Ciuti, Riccardo
AU - D'Onofrio, Paola
AU - Novelli, Annamaria Melani
AU - Pezzati, Marco
AU - Gambi, Davide
AU - Scarselli, Gianfranco
AU - Frigiola, Alessandro
AU - Giamberti, Alessandro
AU - Abella, Raul
AU - Rubaltelli, Firmino F.
PY - 2010/1/6
Y1 - 2010/1/6
N2 - The aim of the No Pain in Labour (NoPiL) study was evaluate the stress and clinical outcome of infants vaginally born without maternal analgesia and after maternal epidural or systemic analgesia. We studied 120 healthy term infants, 41 in the no analgesia group, 38 in the epidural analgesia group, and 41 in the systemic analgesia group. Cortisol, s-endorphin, oxidative stress markers [ie: total hydroperoxide (TH) and advanced oxidation protein products (AOPP)], interleukin-1β (IL-1β), and interleukin-8 (IL-8) cytokines were measured in arterial cord blood samples. Infants in the 3 groups had similar Apgar score, cord blood pH and occurrence of hypoglycaemia, hyperbilirubinemia, and respiratory depression. Cortisol and endorphin plasma levels did not differ in the groups, nor did TH and AOPP values. IL-1β and IL-8 cytokine were higher in infants born after maternal epidural analgesia than in other groups. Short-term outcome and stress were similar in infants vaginally born without maternal analgesia and after epidural and systemic analgesia. The possible implications of the highest interleukin levels in the epidural analgesia group deserve further study.
AB - The aim of the No Pain in Labour (NoPiL) study was evaluate the stress and clinical outcome of infants vaginally born without maternal analgesia and after maternal epidural or systemic analgesia. We studied 120 healthy term infants, 41 in the no analgesia group, 38 in the epidural analgesia group, and 41 in the systemic analgesia group. Cortisol, s-endorphin, oxidative stress markers [ie: total hydroperoxide (TH) and advanced oxidation protein products (AOPP)], interleukin-1β (IL-1β), and interleukin-8 (IL-8) cytokines were measured in arterial cord blood samples. Infants in the 3 groups had similar Apgar score, cord blood pH and occurrence of hypoglycaemia, hyperbilirubinemia, and respiratory depression. Cortisol and endorphin plasma levels did not differ in the groups, nor did TH and AOPP values. IL-1β and IL-8 cytokine were higher in infants born after maternal epidural analgesia than in other groups. Short-term outcome and stress were similar in infants vaginally born without maternal analgesia and after epidural and systemic analgesia. The possible implications of the highest interleukin levels in the epidural analgesia group deserve further study.
KW - Epidural analgesia
KW - Interleukin
KW - Newborn
KW - Oxidative stress
KW - Stress
KW - Systemic analgesia
UR - http://www.scopus.com/inward/record.url?scp=77957347081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957347081&partnerID=8YFLogxK
M3 - Article
C2 - 20515822
AN - SCOPUS:77957347081
VL - 2 E
SP - 1514
EP - 1519
JO - Frontiers in Bioscience - Elite
JF - Frontiers in Bioscience - Elite
SN - 1945-0494
IS - 4
ER -