Effects of epinephrine and vasopressin on cerebral microcirculatory flows during and after cardiopulmonary resuscitation

Giuseppe Ristagno, Shijie Sun, Wanchun Tang, Carlos Castillo, Max Harry Weil

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: Both epinephrine and vasopressin increase aortic and carotid arterial pressure when administered during cardiopulmonary resuscitation. However, we recently demonstrated that epinephrine reduces cerebral cortical microcirculatory blood flow. Accordingly, we compared the effects of nonadrenergic vasopressin with those of epinephrine on cerebral cortical microvascular flow together with cortical tissue Po2 and Pco2 as indicators of cortical tissue ischemia. DESIGN: Randomized, prospective animal study. SETTING: University-affiliated research laboratory. SUBJECTS: Domestic pigs. MEASUREMENTS AND MAIN RESULTS: The tracheae of ten domestic male pigs, weighing 40 ± 2 kg, were noninvasively intubated, and the animals were mechanically ventilated. A frontoparietal bilateral craniotomy was created. Microcirculatory blood flow was quantitated with orthogonal polarization spectral imaging. Blood flow velocity in pial and cortical penetrating vessels measuring

Original languageEnglish
Pages (from-to)2145-2149
Number of pages5
JournalCritical Care Medicine
Volume35
Issue number9
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Cardiac arrest
  • Cardiopulmonary resuscitation
  • Cerebral tissue CO
  • Cerebral tissue oxygen
  • Microcirculation
  • Vasopressor agents

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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