Effects of fexofenadine and other antihistamines on components of the allergic response: Adhesion molecules

Giorgio Ciprandi, Maria Angela Tosca, Cristina Cosentino, Anna Maria Riccio, Giovanni Passalacqua, Giorgio Walter Canonica

Research output: Contribution to journalArticle

Abstract

Intercellular adhesion molecules (ICAMs), in particular ICAM-1, appear to play a crucial role in the recruitment and migration of inflammatory cells to the site of an allergic reaction. Glucocorticoids and allergen-specific immunotherapy have been shown to exert effects on selected components of this system, both in vitro and in vivo, but further research is required to better understand the effects of these therapies. Nasal and conjunctival challenge models (including natural and experimental allergen exposure) represent useful and safe tools for studying the activity of antiallergy drugs in vivo. These tests allow the investigation of a wide variety of parameters including inflammatory infiltrate, ICAM-1 expression, and changes in the concentration of soluble inflammatory mediators. With these tools, anti-inflammatory activity related to the modulation of epithelial cell adhesion molecules has been demonstrated in vivo for several H1-receptor antagonists (azelastine, cetirizine, loratadine, levocabastine, oxatomide, and terfenadine). Fexofenadine is a nonsedating, long-acting antihistamine with highly selective H1-receptor antagonist activity and a particularly favorable safety profile. In addition, fexofenadine has proven anti-inflammatory activity and has been shown to inhibit a number of mediators at clinically relevant concentrations, including in vitro inhibition of ICAM-1 expression on conjunctival and nasal epithelial cells.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Volume112
Issue number4 SUPPL.
DOIs
Publication statusPublished - Oct 1 2003

Keywords

  • Allergic inflammation
  • Antihistamines
  • ICAM-1
  • Intercellular adhesion molecules

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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