Effects of flecainide and propafenone on systolic performance in subjects with normal cardiac function

V. Santinelli, M. Arnese, I. Oppo, C. Matarazzi, S. Maione, M. Palma, A. Giunta

Research output: Contribution to journalArticlepeer-review

Abstract

Flecainide and propafenone are effective in suppressing both ventricular and supraventricular tachyarrhythmias, but their efficacy is often limited by dose-related side effects. This study was performed to evaluate noninvasively the effects of intravenous flecainide and propafenone on left ventricular systolic function indices in a selected population of 40 subjects (28 men and 12 women; mean age, 25 years) with normal cardiac structure and performance. Echocardiographic indexes of global systolic pump function (ejection fraction [EF] and percentage of fractional shortening [percent FS]) as well as monodimensional parameters of the interventricular septum (IVS) and left ventricular posterior wall (PW) contractility (percent systolic thickening [percent th] and systolic excursion [ex]) were assessed in all subjects at baseline, immediately after, and in the early recovery (15 min) after randomized injection of either flecainide or propafenone. Heart rate and blood pressure did not significantly change after both drugs. A significant increase (p

Original languageEnglish
Pages (from-to)1068-1073
Number of pages6
JournalChest
Volume103
Issue number4
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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