Effects of flecainide on dispersion of atrial refractoriness in paroxysmal atrial fibrillation

L. Padeletti, A. Michelucci, M. C. Porciani, A. Mezzani, A. Chelucci, M. Bamoshmoosh, C. Rostagno, L. Poggesi, G. F. Gensini

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Abstract

Flecainide (Fl) is employed to convert atrial fibrillation into sinus rhythm and to prevent paroxysmal atrial fibrillation (PAF). One of the mechanisms involved in the genesis of PAF is an abnormal dispersion (D) of atrial refractoriness. We investigated the effects of Fl on D of effective (E) and functional (F) atrial refractory periods (ARP) in 10 patients (6 M and 4 F, mean age 54 ± 13 years) with recurrent episodes of PAF. Programmed stimulation was performed in each patient at three right atrial sites (high, medium, and low lateral wall) before and after intravenous Fl (2 mg/Kg body weight) was administered over 15 minutes. DEARP and DFARP were the differences between the maximum and the minimum value of EARP and FARP at each stimulation site. DEARP and DFARP were significantly decreased after Fl was administered (49 ± 24 ms vs 92 ± 61 ms, p <0.05, and 40 ± 29 ms vs 90 ± 52 ms, p <0.004, respectively). In conclusion, our data suggest that Fl, by significantly reducing DEARP and DFARP, can make the electrophysiologic properties of atrial tissue more homogeneous thus preventing recurrences of PAF.

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalNew Trends in Arrhythmias
Volume9
Issue number4
Publication statusPublished - 1993

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Keywords

  • atrial fibrillation
  • atrial wavelength
  • dispersion of atrial refractoriness
  • flecainide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Padeletti, L., Michelucci, A., Porciani, M. C., Mezzani, A., Chelucci, A., Bamoshmoosh, M., Rostagno, C., Poggesi, L., & Gensini, G. F. (1993). Effects of flecainide on dispersion of atrial refractoriness in paroxysmal atrial fibrillation. New Trends in Arrhythmias, 9(4), 1005-1012.