Effects of fluoxetine, indomethacine and placebo on 3α, 5α tetrahydroprogesterone (THP) plasma levels in uncomplicated alcohol withdrawal

Elena Romeo, Enrico Pompili, Flavia Di Michele, Mauro Pace, Rainer Rupprecht, Giorgio Bernardi, Augusto Pasinib

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The purpose of this study was to investigate the effects of fluoxetine (F) and indomethacine (I), two drugs that regulate the synthesis of the GABAergic neurosteroid 3α, 5α tetrahydroprogesterone (allopregnanolone, THP) on THP plasma levels and on symptoms of anxiety and depression in alcoholics during ethanol withdrawal. Method: Patients who met DSM-IV criteria for alcohol abuse were randomly assigned to treatment with F (40 mg/day) plus misoprostol (M) (500 mg/day) or I (100 mg/day) plus M or placebo (PL) plus M. Patients were rated with the Hamilton Anxiety (14-HAS) and Depression (17-HDS) scales on days 1, 5, 7, 15 and 28 of ethanol withdrawal and with a Visual Analogue Scale for Depression (VASD) and a Visual Analogue Scale for Anxiety (VASA) on days 1, 2, 4, 5, 7, 15 and 28 of withdrawal. On the same days a plasma sample was collected to measure the concentrations of THP by means of a very sensitive gas chromatographic mass spectrometric method. Results: During withdrawal at days 1, 2, 4 and 5, THP plasma values were lower and symptoms of anxiety and depression were significantly higher compared to the late withdrawal phase at days 15 and 28. In the F or I treatment, the depression and anxiety score, measured by VASD and VASA, decreased significantly at day 5-7 whereas THP plasma levels significantly increased compared to PL condition. Conclusions: Treatment of alcohol withdrawal either with F or I reduced the extent of anxiety and depression and normalised THP plasma levels that were decreased during withdrawal.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalWorld Journal of Biological Psychiatry
Volume1
Issue number2
DOIs
Publication statusPublished - 2000

Keywords

  • ethanol
  • fluoxetine
  • indomethacine
  • neurosteroids
  • steroids

ASJC Scopus subject areas

  • Biological Psychiatry
  • Psychiatry and Mental health

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