Based on the evidence of its antiepileptic activity in experimental models of epilepsy, fluoxetine have been tested as an add-on drug in the treatment of medically intractable epilepsy. Nine patients with focal or secondary generalized epilepsy received 20 mg/die of fluoxetine for one month, followed by another month with 40 mg/die in seven of them. No significant improvement was observed. In addition, side effects of the aggressive type were observed. This preliminary study does not confirm the experimental evidence of antiepileptic effectiveness of fluoxetine and discourages its use as an antidepressive agent in epileptic patients.
|Translated title of the contribution||Effects of fluoxetine treatment in patients with focal epilepsy and with secondary generalized epilepsy|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Clinical Neurology