Effects of fluvoxamine and citalopram in maintaining abstinence in a sample of Italian detoxified alcoholics

Sara M. Angelone, Laura Bellini, Daniela Di Bella, Marco Catalano

Research output: Contribution to journalArticlepeer-review

Abstract

A 16-week, randomized study was performed to test the efficacy of two selective serotonin reuptake inhibitors (SSRIs) fluvoxamine and citalopram, in decreasing relapse and craving in alcoholics, and to investigate possible differences in their clinical profile. After detoxification, each of the 81 patients (55 males and 26 females) was randomly assigned to one of three groups: 23 subjects did not receive any pharmacological treatment, 25 were treated with fluvoxamine, 150 mg/day, and 33 with citalopram, 20 mg/day. All patients received standard cognitive-behavioural therapy. Craving was assessed twice a month using a 10-step scale. Every intake of alcohol was considered a relapse and the subject was taken out of the study. At the end of the study, both the fluvoxamine and citalopram groups showed a statistically higher rate of continuous abstinence (63.6 and 60.7%, respectively) compared to the group without pharmacological treatment (30.4%). Relapse severity did not differ among the three groups. Only citalopram showed a significant effect on craving throughout the study period. This study confirmed the efficacy of SSRIs as an adjunct to psychotherapy to prevent relapse in alcoholics. The relationship between the effects of these SSRIs on abstinence and craving, as well as the differences between their profiles, are discussed.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalAlcohol and Alcoholism
Volume33
Issue number2
Publication statusPublished - Mar 1998

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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