Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man

F. Cavagnini, M. Pinto, A. Dubini, C. Invitti, G. Cappelletti, E. E. Polli

Research output: Contribution to journalArticle

Abstract

The high concentrations of gamma aminobutyric acid (GABA) in the pancreatic islets and the neurotransmitter role played by this amino acid in the central nervous system, make it plausible that GABA also intervenes in the control of endocrine pancreatic function. In 12 normal subjects, a single oral dose of 5 or 10 g GABA, as compared to placebo, caused a significant (p <0.01) and dose-dependent (p <0.01) increase of plasma levels of immunoreactive insulin, C peptide and glucagon, without affecting plasma glucose concentration. By contrast, in 15 additional subjects, a single oral dose of 5 mg muscimol, a specific GABA receptor agonist, did not consistently influence the above parameters. Although the lack of effects of muscimol might indicate that the action of GABA is not mediated through specific receptors, the results with GABA suggest that this amino acid plays a specific role in the regulation of endocrine pancreatic function.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalMetabolism
Volume31
Issue number1
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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