Effects of gastric banding on glucose tolerance, cardiovascular and renal function, and diabetic complications: A 13-year study of the morbidly obese

Ahmed S. Zakaria, Luca Rossetti, Maurizio Cristina, Anna Veronelli, Federico Lombardi, Alessandro Saibene, Giancarlo Micheletto, Antonio E. Pontiroli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Limited information is available on weight loss, metabolic control, cardiovascular disease and diabetic complications in morbidly obese patients undergoing gastric banding (LAGB) compared with morbidly obese patients receiving medical treatment. Objective: To assess the long-term effects of laparoscopic adjustable gastric banding (LAGB) on glucose tolerance, arterial hypertension, and cardiovascular disease and prevention of diabetic complications (retinopathy and renal function) in morbidly obese patients. Setting: University hospitals, Italy. Materials and Methods: In this retrospective study, 87 morbidly obese patients who underwent LAGB (20 with diabetes) and 87 morbidly obese patients who did not undergo surgery (36 with diabetes) for the treatment of obesity during the period 1995 to 2003 consented for re-examination after a mean (±standard deviation) period of 13.8±2.04 years. At baseline, all mobidly obese patients had a body mass index (BMI)≥35 kg/m2 and were aged 18 to 65 years. Results: At follow-up, LAGB patients maintained a lower weight compared with baseline values and demonstrated significant decreases in both blood pressure and heart rate measurements compared with control patients. LAGB patients also experienced greater improvement of glucose tolerance than did control patients (28% versus 10%, respectively; P2), improvement of glucose tolerance persisted for long periods after LAGB, with no unfavorable effect on kidney function and retinopathy. In contrast, no effect was observed on prevention of arterial hypertension or cardiovascular disease.

Original languageEnglish
Pages (from-to)587-895
Number of pages9
JournalSurgery for Obesity and Related Diseases
Volume12
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • Arterial hypertension
  • Bariatric surgery
  • Cardiovascular diseases
  • Diabetes mellitus
  • Diabetic retinopathy
  • Glomerular filtration rate
  • Glucose tolerance
  • Homeostasis model assessment
  • Insulin resistance
  • Laparoscopic adjustable gastric banding
  • Morbid obesity
  • Renal function

ASJC Scopus subject areas

  • Surgery

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