Effects of Glucose-Insulin-Potassium Infusion on Myocardial Perfusion and Left Ventricular Remodeling in Patients Treated With Primary Angioplasty for ST-Elevation Acute Myocardial Infarction

Chiara Bucciarelli-Ducci, Maria Bianchi, Leonardo De Luca, Alessandro Battagliese, Cristian Di Russo, Paola Proietti, Carmine D. Vizza, Francesco Fedele

Research output: Contribution to journalArticlepeer-review

Abstract

The role of glucose-insulin-potassium (GIK) infusion in the management of acute coronary syndrome is controversial. Limited data are available on the effects of adjunctive high-dose GIK (30% glucose, 50 IU of insulin, 80 mEq of potassium chloride infused at 1.5 ml/kg/hour over 24 hours) on myocardial perfusion and left ventricular (LV) remodeling in patients treated with primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction. In this prospective study, 73 patients were randomized to receive GIK infusion (n = 40) or saline (placebo, n = 33) in addition to standard therapy. The primary end points were myocardial perfusion after PCI and LV remodeling at 6 months. Thrombolysis In Myocardial Infarction frame count and myocardial blush grade were evaluated before and after reperfusion treatment. LV end-diastolic and end-systolic volumes, ejection fraction, and wall motion score index were assessed in each patient after PCI and after 6 months. Although no differences in final Thrombolysis In Myocardial Infarction flow were observed between the 2 groups, myocardial blush grade 3 was more frequently achieved in the GIK group (p

Original languageEnglish
Pages (from-to)1349-1353
Number of pages5
JournalThe American Journal of Cardiology
Volume98
Issue number10
DOIs
Publication statusPublished - Nov 15 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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