Effects of growth hormone (GH) treatment on cardiac structure and function in adults with GH deficiency

A. Sartorio, S. Ferrero, A. Conti, R. Romaniello, R. Bragato, G. Leonetti, F. Morabito, G. Faglia

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Cardiac structure and function were evaluated, by means of two- dimensional, M-mode and Doppler echo-cardiograms, in 8 adults with childhood- onset GH deficiency (GHD), before and after six months of GH therapy (0.15 IU/kg/week). Stress test was also performed by means of a modified Bruce protocol with a bicycle ergometer. The data obtained from the patients were compared with those recorded in a sex, age, body mass index (kg/m2, BMI) and exercise matched control group. Before treatment, the means (±SE) intraventricular septal thickness (IVST: 7.1±0.2 mm), LV posterior wall thickness (LVPT: 5.2±0.1 mm), LV mass index (LVM/body surface area, LVMI: 65.1±3.0 g/m2), left ventricular end-diastolic diameter (LVED: 41.4±0.6 mm) and LV ejection time (LVET: 248.7±7.9 msec) of the patients were significantly lower than controls, while PEV/LVET (0.36±0.01) values were significantly higher. LV end-systolic diameter (LVES: 25.5±0.7 mm), LV preejection period (PEP: 88.9±1.1 msec), ejection fraction (EF: 67.8±2.1) and parameters of LV diastolic function (peak E: 67.6±3.4 cm/sec, peak A: 39.1±5.5 cm/sec, E/A ratio: 1.8±0.2) of the patients were similar to controls'. GH treatment significantly increased LVPT (6.8±0.2 mm) and LVMI (80.5±3.5 g/m2) and conversely, reduced PEP (76.9±1.9 msec), LVET (233.7±6.8 msec) and PEP/LVET values (0.32±0.01); no significant changes were observed for the other parameters. The stress test showed a significant improvements in cardiac performance, as demonstrated by the reduction in blood pressure x heart rate product at the same workload (basal: 32722±897.4 vs. after: 25.574.6±439.7, p.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalActa Medica Auxologica
Issue number1
Publication statusPublished - 1998


  • Adulthood
  • Cardiac function
  • Cardiac structure
  • GH deficiency
  • GH therapy

ASJC Scopus subject areas

  • Medicine(all)


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