Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride

H. Uzumaki, S. Govoni, M. Memo, M. O. Carruba, M. Trabucchi, P. F. Spano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

[3H]Lisuride binding to rat striatal membranes appeared to be stereospecifically displaced by the dopamine antagonist butaclamol. Sodium increased the number of [3H]lisuride binding sites (Bmax) without changing the dissciation constant (Kd). GTP did not affect [3H]lisuride binding characteristics, either with or without sodium. These results suggest that dopamine receptor sites labeled by lisuride are at least in part sodium-dependent, possibly the D2-receptors not involved in adenylate cyclase stimulation.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalBrain Research
Volume248
Issue number1
DOIs
Publication statusPublished - Sep 23 1982

Fingerprint

Lisuride
Corpus Striatum
Dopamine Receptors
Guanosine Triphosphate
Sodium
Butaclamol
Dopamine Antagonists
Adenylyl Cyclases
Binding Sites
Membranes

Keywords

  • dopamine receptor
  • GTP
  • lisuride
  • sodium

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Uzumaki, H., Govoni, S., Memo, M., Carruba, M. O., Trabucchi, M., & Spano, P. F. (1982). Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride. Brain Research, 248(1), 185-187. https://doi.org/10.1016/0006-8993(82)91162-3

Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride. / Uzumaki, H.; Govoni, S.; Memo, M.; Carruba, M. O.; Trabucchi, M.; Spano, P. F.

In: Brain Research, Vol. 248, No. 1, 23.09.1982, p. 185-187.

Research output: Contribution to journalArticle

Uzumaki, H, Govoni, S, Memo, M, Carruba, MO, Trabucchi, M & Spano, PF 1982, 'Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride', Brain Research, vol. 248, no. 1, pp. 185-187. https://doi.org/10.1016/0006-8993(82)91162-3
Uzumaki H, Govoni S, Memo M, Carruba MO, Trabucchi M, Spano PF. Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride. Brain Research. 1982 Sep 23;248(1):185-187. https://doi.org/10.1016/0006-8993(82)91162-3
Uzumaki, H. ; Govoni, S. ; Memo, M. ; Carruba, M. O. ; Trabucchi, M. ; Spano, P. F. / Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride. In: Brain Research. 1982 ; Vol. 248, No. 1. pp. 185-187.
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