Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride

H. Uzumaki, S. Govoni, M. Memo, M. O. Carruba, M. Trabucchi, P. F. Spano

Research output: Contribution to journalArticle

Abstract

[3H]Lisuride binding to rat striatal membranes appeared to be stereospecifically displaced by the dopamine antagonist butaclamol. Sodium increased the number of [3H]lisuride binding sites (Bmax) without changing the dissciation constant (Kd). GTP did not affect [3H]lisuride binding characteristics, either with or without sodium. These results suggest that dopamine receptor sites labeled by lisuride are at least in part sodium-dependent, possibly the D2-receptors not involved in adenylate cyclase stimulation.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalBrain Research
Volume248
Issue number1
DOIs
Publication statusPublished - Sep 23 1982

Keywords

  • dopamine receptor
  • GTP
  • lisuride
  • sodium

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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    Uzumaki, H., Govoni, S., Memo, M., Carruba, M. O., Trabucchi, M., & Spano, P. F. (1982). Effects of GTP and sodium on rat striatal dopamine receptors labeled with lisuride. Brain Research, 248(1), 185-187. https://doi.org/10.1016/0006-8993(82)91162-3