Abstract
To investigate the origin, the mechanisms of regulation and the possible biological significance of inactive renin we examined the effects of haemodialysis on plasma active and inactive (cryoactivatable) renin in four anephric and in 10 nephric patients. Before haemodialysis inactive renin was similar in anephric and in the majority of nephric patients; this suggests that the source of the inactive enzyme is predominantly extrarenal. In response to haemodialysis active renin rose significantly in nephric patients whereas inactive renin showed minor and inconsistent increments in both groups. These results indicate that the response of the inactive enzyme to haemodialysis is less than that of its active counterpart and is unaffected by the presence of the kidneys. Therefore, it appears unlikely that inactive renin represents a circulating precursor of active renin.
| Original language | English |
|---|---|
| Pages (from-to) | 514-519 |
| Number of pages | 6 |
| Journal | Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association |
| Volume | 20 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Medicine(all)
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Effects of haemodialysis on active and inactive renin in nephric and anephric patients. / Vendemia, F.; Morganti, A.; Scalia, A.; Sala, C.; Turolo, L.; D'Amico, G.
In: Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, Vol. 20, 1983, p. 514-519.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of haemodialysis on active and inactive renin in nephric and anephric patients.
AU - Vendemia, F.
AU - Morganti, A.
AU - Scalia, A.
AU - Sala, C.
AU - Turolo, L.
AU - D'Amico, G.
PY - 1983
Y1 - 1983
N2 - To investigate the origin, the mechanisms of regulation and the possible biological significance of inactive renin we examined the effects of haemodialysis on plasma active and inactive (cryoactivatable) renin in four anephric and in 10 nephric patients. Before haemodialysis inactive renin was similar in anephric and in the majority of nephric patients; this suggests that the source of the inactive enzyme is predominantly extrarenal. In response to haemodialysis active renin rose significantly in nephric patients whereas inactive renin showed minor and inconsistent increments in both groups. These results indicate that the response of the inactive enzyme to haemodialysis is less than that of its active counterpart and is unaffected by the presence of the kidneys. Therefore, it appears unlikely that inactive renin represents a circulating precursor of active renin.
AB - To investigate the origin, the mechanisms of regulation and the possible biological significance of inactive renin we examined the effects of haemodialysis on plasma active and inactive (cryoactivatable) renin in four anephric and in 10 nephric patients. Before haemodialysis inactive renin was similar in anephric and in the majority of nephric patients; this suggests that the source of the inactive enzyme is predominantly extrarenal. In response to haemodialysis active renin rose significantly in nephric patients whereas inactive renin showed minor and inconsistent increments in both groups. These results indicate that the response of the inactive enzyme to haemodialysis is less than that of its active counterpart and is unaffected by the presence of the kidneys. Therefore, it appears unlikely that inactive renin represents a circulating precursor of active renin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020995870&partnerID=8YFLogxK
M3 - Article
C2 - 6361756
AN - SCOPUS:0020995870
VL - 20
SP - 514
EP - 519
JO - Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
JF - Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
SN - 0071-2736
ER -