Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAs in the rat

Brunella Caronti, Francesca Passarelli, Caterina Calderaro, Guido Palladini, Francesco E. Pontieri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the effects of haloperidol treatment (1 mg/kg/day for 2, 7 or 21 consecutive days) on the expression of D1B and D3 dopamine receptor mRNAs in the rat lymphocytes. The expression of D1B receptor mRNA was significantly decreased after 2 days of treatment and progressively returned toward basal values at the end of treatment. Conversely, haloperidol failed to modify the expression of lymphocyte D3 receptor mRNA. These results indicate short- lasting dynamic changes of expression of lymphocyte D1B dopamine receptor mRNA by haloperidol and suggest that the effects of dopamine and dopaminergic drugs on the immune system might be mediated, at least in part, by direct interaction of these substances with dopamine receptors on lymphocyte membrane.

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume23
Issue number5
DOIs
Publication statusPublished - Jul 1999

Fingerprint

Dopamine Receptors
Haloperidol
Dopamine D5 Receptors
Lymphocytes
Dopamine Agents
Messenger RNA
Dopamine D3 Receptors
Reverse Transcriptase Polymerase Chain Reaction
Immune System
Membranes

Keywords

  • Dopamine
  • Dopamine receptors
  • Haloperidol
  • Lymphocytes
  • MRNA
  • RT-PCR

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAs in the rat. / Caronti, Brunella; Passarelli, Francesca; Calderaro, Caterina; Palladini, Guido; Pontieri, Francesco E.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 23, No. 5, 07.1999, p. 851-859.

Research output: Contribution to journalArticle

Caronti, Brunella ; Passarelli, Francesca ; Calderaro, Caterina ; Palladini, Guido ; Pontieri, Francesco E. / Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAs in the rat. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1999 ; Vol. 23, No. 5. pp. 851-859.
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