Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAs in the rat

Brunella Caronti, Francesca Passarelli, Caterina Calderaro, Guido Palladini, Francesco E. Pontieri

Research output: Contribution to journalArticle

Abstract

Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the effects of haloperidol treatment (1 mg/kg/day for 2, 7 or 21 consecutive days) on the expression of D1B and D3 dopamine receptor mRNAs in the rat lymphocytes. The expression of D1B receptor mRNA was significantly decreased after 2 days of treatment and progressively returned toward basal values at the end of treatment. Conversely, haloperidol failed to modify the expression of lymphocyte D3 receptor mRNA. These results indicate short- lasting dynamic changes of expression of lymphocyte D1B dopamine receptor mRNA by haloperidol and suggest that the effects of dopamine and dopaminergic drugs on the immune system might be mediated, at least in part, by direct interaction of these substances with dopamine receptors on lymphocyte membrane.

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume23
Issue number5
DOIs
Publication statusPublished - Jul 1999

Keywords

  • Dopamine
  • Dopamine receptors
  • Haloperidol
  • Lymphocytes
  • MRNA
  • RT-PCR

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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