Effects of heart rate changes on arterial distensibility in humans

Cristina Giannattasio, Antonio Vincenti, Monica Failla, Anna Capra, Antonio Cirò, Sergio De Ceglia, Gaetano Gentile, Roberta Brambilla, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

In rats, an increase in heart rate by pacing is accompanied by progressive large-artery stiffening. Whether this is also the case in humans is unknown. We enrolled 20 patients who were chronically implanted with a pacemaker because of atrioventricular block or sick sinus syndrome. Arterial distensibility was measured by an echo-tracking device. In 10 patients, the evaluation was performed on the radial artery by using continuous finger blood pressure measurements, whereas in the remaining 10 patients, the common carotid artery was studied with a semiautomatic measure of brachial artery blood pressure. Diastolic diameter, systodiastolic diameter change, and distensibility were obtained at baseline (heart rate 63±2 beats/min) and after atrial and ventricular sequential pacing at a heart rate of 90 and 110 beats/min. At baseline, the diameter was 7.8±0.3 mm in the carotid artery and 2.4±0.1 mm in the radial artery; the respective systodiastolic diameter change values were 375.4±31.0 and 55.9±9.0 (μm) and the distensibility values were 1.4±0.1 and 0.7±0.1 (1/mm Hg 10 -3). Blood pressure and diameter were not significantly modified by increasing heart rate, which markedly modified systodiastolic diameter change and distensibility. In the radial artery, distensibility was reduced by 47% (P

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalHypertension
Volume42
Issue number3
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Radial Artery
Heart Rate
Blood Pressure
Sick Sinus Syndrome
Brachial Artery
Atrioventricular Block
Common Carotid Artery
Carotid Arteries
Fingers
Arteries
Equipment and Supplies

Keywords

  • Arterial stiffness
  • Heart rate
  • Human
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Giannattasio, C., Vincenti, A., Failla, M., Capra, A., Cirò, A., De Ceglia, S., ... Mancia, G. (2003). Effects of heart rate changes on arterial distensibility in humans. Hypertension, 42(3), 253-256. https://doi.org/10.1161/01.HYP.0000085199.33254.15

Effects of heart rate changes on arterial distensibility in humans. / Giannattasio, Cristina; Vincenti, Antonio; Failla, Monica; Capra, Anna; Cirò, Antonio; De Ceglia, Sergio; Gentile, Gaetano; Brambilla, Roberta; Mancia, Giuseppe.

In: Hypertension, Vol. 42, No. 3, 01.09.2003, p. 253-256.

Research output: Contribution to journalArticle

Giannattasio, C, Vincenti, A, Failla, M, Capra, A, Cirò, A, De Ceglia, S, Gentile, G, Brambilla, R & Mancia, G 2003, 'Effects of heart rate changes on arterial distensibility in humans', Hypertension, vol. 42, no. 3, pp. 253-256. https://doi.org/10.1161/01.HYP.0000085199.33254.15
Giannattasio C, Vincenti A, Failla M, Capra A, Cirò A, De Ceglia S et al. Effects of heart rate changes on arterial distensibility in humans. Hypertension. 2003 Sep 1;42(3):253-256. https://doi.org/10.1161/01.HYP.0000085199.33254.15
Giannattasio, Cristina ; Vincenti, Antonio ; Failla, Monica ; Capra, Anna ; Cirò, Antonio ; De Ceglia, Sergio ; Gentile, Gaetano ; Brambilla, Roberta ; Mancia, Giuseppe. / Effects of heart rate changes on arterial distensibility in humans. In: Hypertension. 2003 ; Vol. 42, No. 3. pp. 253-256.
@article{ad2f79a3b45840839d0b60331a7c6118,
title = "Effects of heart rate changes on arterial distensibility in humans",
abstract = "In rats, an increase in heart rate by pacing is accompanied by progressive large-artery stiffening. Whether this is also the case in humans is unknown. We enrolled 20 patients who were chronically implanted with a pacemaker because of atrioventricular block or sick sinus syndrome. Arterial distensibility was measured by an echo-tracking device. In 10 patients, the evaluation was performed on the radial artery by using continuous finger blood pressure measurements, whereas in the remaining 10 patients, the common carotid artery was studied with a semiautomatic measure of brachial artery blood pressure. Diastolic diameter, systodiastolic diameter change, and distensibility were obtained at baseline (heart rate 63±2 beats/min) and after atrial and ventricular sequential pacing at a heart rate of 90 and 110 beats/min. At baseline, the diameter was 7.8±0.3 mm in the carotid artery and 2.4±0.1 mm in the radial artery; the respective systodiastolic diameter change values were 375.4±31.0 and 55.9±9.0 (μm) and the distensibility values were 1.4±0.1 and 0.7±0.1 (1/mm Hg 10 -3). Blood pressure and diameter were not significantly modified by increasing heart rate, which markedly modified systodiastolic diameter change and distensibility. In the radial artery, distensibility was reduced by 47{\%} (P",
keywords = "Arterial stiffness, Heart rate, Human, Risk factors",
author = "Cristina Giannattasio and Antonio Vincenti and Monica Failla and Anna Capra and Antonio Cir{\`o} and {De Ceglia}, Sergio and Gaetano Gentile and Roberta Brambilla and Giuseppe Mancia",
year = "2003",
month = "9",
day = "1",
doi = "10.1161/01.HYP.0000085199.33254.15",
language = "English",
volume = "42",
pages = "253--256",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effects of heart rate changes on arterial distensibility in humans

AU - Giannattasio, Cristina

AU - Vincenti, Antonio

AU - Failla, Monica

AU - Capra, Anna

AU - Cirò, Antonio

AU - De Ceglia, Sergio

AU - Gentile, Gaetano

AU - Brambilla, Roberta

AU - Mancia, Giuseppe

PY - 2003/9/1

Y1 - 2003/9/1

N2 - In rats, an increase in heart rate by pacing is accompanied by progressive large-artery stiffening. Whether this is also the case in humans is unknown. We enrolled 20 patients who were chronically implanted with a pacemaker because of atrioventricular block or sick sinus syndrome. Arterial distensibility was measured by an echo-tracking device. In 10 patients, the evaluation was performed on the radial artery by using continuous finger blood pressure measurements, whereas in the remaining 10 patients, the common carotid artery was studied with a semiautomatic measure of brachial artery blood pressure. Diastolic diameter, systodiastolic diameter change, and distensibility were obtained at baseline (heart rate 63±2 beats/min) and after atrial and ventricular sequential pacing at a heart rate of 90 and 110 beats/min. At baseline, the diameter was 7.8±0.3 mm in the carotid artery and 2.4±0.1 mm in the radial artery; the respective systodiastolic diameter change values were 375.4±31.0 and 55.9±9.0 (μm) and the distensibility values were 1.4±0.1 and 0.7±0.1 (1/mm Hg 10 -3). Blood pressure and diameter were not significantly modified by increasing heart rate, which markedly modified systodiastolic diameter change and distensibility. In the radial artery, distensibility was reduced by 47% (P

AB - In rats, an increase in heart rate by pacing is accompanied by progressive large-artery stiffening. Whether this is also the case in humans is unknown. We enrolled 20 patients who were chronically implanted with a pacemaker because of atrioventricular block or sick sinus syndrome. Arterial distensibility was measured by an echo-tracking device. In 10 patients, the evaluation was performed on the radial artery by using continuous finger blood pressure measurements, whereas in the remaining 10 patients, the common carotid artery was studied with a semiautomatic measure of brachial artery blood pressure. Diastolic diameter, systodiastolic diameter change, and distensibility were obtained at baseline (heart rate 63±2 beats/min) and after atrial and ventricular sequential pacing at a heart rate of 90 and 110 beats/min. At baseline, the diameter was 7.8±0.3 mm in the carotid artery and 2.4±0.1 mm in the radial artery; the respective systodiastolic diameter change values were 375.4±31.0 and 55.9±9.0 (μm) and the distensibility values were 1.4±0.1 and 0.7±0.1 (1/mm Hg 10 -3). Blood pressure and diameter were not significantly modified by increasing heart rate, which markedly modified systodiastolic diameter change and distensibility. In the radial artery, distensibility was reduced by 47% (P

KW - Arterial stiffness

KW - Heart rate

KW - Human

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=0041833325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041833325&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.0000085199.33254.15

DO - 10.1161/01.HYP.0000085199.33254.15

M3 - Article

C2 - 12913054

AN - SCOPUS:0041833325

VL - 42

SP - 253

EP - 256

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3

ER -