Effects of hematocrit changes on flow-mediated and metabolic vasodilation in humans

Cristina Giannattasio, Alberto Piperno, Monica Failla, Anna Vergani, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

Endothelial function is noninvasively assessed by measuring nitric oxide-dependent increase in radial artery diameter accompanying the elevation in shear stress induced by increasing blood flow through a short-lasting ischemia of the hand. However, shear stress also depends on blood viscosity, whose changes might thus affect nitric oxide increase in a manner that is not properly reflected by blood flow changes. In 12 subjects with hemochromatosis, we measured ultrasonographically radial artery diameter and blood flow responses to a 4-minute ischemia of the hand. This was done also after removing 500 mL of blood (and concomitantly infusing 500 mL of saline), which significantly (P

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalHypertension
Volume40
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Hematocrit
Vasodilation
Radial Artery
Nitric Oxide
Ischemia
Hand
Blood Viscosity
Hemochromatosis

Keywords

  • Blood flow
  • Endothelium
  • Hemoglobin
  • Vasodilation
  • Viscosity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Effects of hematocrit changes on flow-mediated and metabolic vasodilation in humans. / Giannattasio, Cristina; Piperno, Alberto; Failla, Monica; Vergani, Anna; Mancia, Giuseppe.

In: Hypertension, Vol. 40, No. 1, 2002, p. 74-77.

Research output: Contribution to journalArticle

Giannattasio, C, Piperno, A, Failla, M, Vergani, A & Mancia, G 2002, 'Effects of hematocrit changes on flow-mediated and metabolic vasodilation in humans', Hypertension, vol. 40, no. 1, pp. 74-77. https://doi.org/10.1161/01.HYP.0000022571.86090.F3
Giannattasio, Cristina ; Piperno, Alberto ; Failla, Monica ; Vergani, Anna ; Mancia, Giuseppe. / Effects of hematocrit changes on flow-mediated and metabolic vasodilation in humans. In: Hypertension. 2002 ; Vol. 40, No. 1. pp. 74-77.
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