Effects of hematocrit changes on flow-mediated and metabolic vasodilation in humans

Cristina Giannattasio, Alberto Piperno, Monica Failla, Anna Vergani, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Endothelial function is noninvasively assessed by measuring nitric oxide-dependent increase in radial artery diameter accompanying the elevation in shear stress induced by increasing blood flow through a short-lasting ischemia of the hand. However, shear stress also depends on blood viscosity, whose changes might thus affect nitric oxide increase in a manner that is not properly reflected by blood flow changes. In 12 subjects with hemochromatosis, we measured ultrasonographically radial artery diameter and blood flow responses to a 4-minute ischemia of the hand. This was done also after removing 500 mL of blood (and concomitantly infusing 500 mL of saline), which significantly (P

Original languageEnglish
Pages (from-to)74-77
Number of pages4
Issue number1
Publication statusPublished - 2002


  • Blood flow
  • Endothelium
  • Hemoglobin
  • Vasodilation
  • Viscosity

ASJC Scopus subject areas

  • Internal Medicine


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