Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases

Ilaria Peluso, Anna Raguzzini, Giovina Catasta, Vittoria Cammisotto, Anna Perrone, Carlo Tomino, Elisabetta Toti, Mauro Serafini

Research output: Contribution to journalArticle

Abstract

High intakes of vegetables have been associated with a lower incidence of cardiovascular diseases (CVD). However, the effect of vegetables on immune function and antioxidant status in human studies have provided contrasting results. In the present study, after a week of run-in period, 38 subjects at risk of CVD were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week). Vegetables included carrots, topinambur (Jerusalem artichoke, Helianthus tuberosus), tomatoes, red cabbage, and sweet peppers. Blood and salivary samples were collected before and after intervention periods. In addition to clinical, immunological, and antioxidant markers, leukocyte and lymphocyte expression of the gut-homing β7 integrin was evaluated. No significant changes were detected in clinical, immunological, and antioxidant markers in biological samples, except for an increase in white blood cell count for the low vegetable consumption group (p < 0.05). The study provides additional evidence about the uncertainty of providing a clear evidence for vegetables in modulating markers of immune function and antioxidant status. Further studies are needed in order to unravel the mechanism of effect of vegetable consumption in cardiovascular prevention.

Original languageEnglish
JournalOxidative Medicine and Cellular Longevity
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Vegetables
Cardiovascular Diseases
Antioxidants
Capsicum
Helianthus
Blood
Biomarkers
Daucus carota
Lymphocytes
Brassica
Lycopersicon esculentum
Leukocyte Count
Integrins
Uncertainty
Leukocytes
Cells
Incidence

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases. / Peluso, Ilaria; Raguzzini, Anna; Catasta, Giovina; Cammisotto, Vittoria; Perrone, Anna; Tomino, Carlo; Toti, Elisabetta; Serafini, Mauro.

In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 01.01.2018.

Research output: Contribution to journalArticle

Peluso, Ilaria ; Raguzzini, Anna ; Catasta, Giovina ; Cammisotto, Vittoria ; Perrone, Anna ; Tomino, Carlo ; Toti, Elisabetta ; Serafini, Mauro. / Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases. In: Oxidative Medicine and Cellular Longevity. 2018 ; Vol. 2018.
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