Effects of High-Dose IgG on Survival of Surgical Patients with Sepsis Scores of 20 or Greater

Lorenzo Dominioni, Renzo Dionigi, Marco Zanello, Maurizio Chiaranda, Roberto Dionigi, Annamaria Acquarolo, Andrea Ballabio, Chiara Sguotti

Research output: Contribution to journalArticle

Abstract

Sixty-two consecutive septic surgical patients receiving standard multimodal intensive care unit treatment who developed a sepsis score of 20 or greater (day 0) were randomized to receive 0.4 g/kg of either intravenous IgG (29 patients) or human albumin (controls; 33 patients), repeated on days +1 and + 5, in a prospective, double-blind, multicenter study. The two groups were similar in age, initial sepsis scores, and acute physiology and chronic health evaluation II score. A significantly lower mortality was recorded in the IgG-treated group (38%) than in controls (67%). Septic shock was the cause of death in 7% of IgG-treated patients and in 33% of controls. The results of this study indicate that high-dose IgG improves survival and decreases death from septic shock in surgical patients with a sepsis score of 20 or greater.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalArchives of Surgery
Volume126
Issue number2
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Surgery

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    Dominioni, L., Dionigi, R., Zanello, M., Chiaranda, M., Dionigi, R., Acquarolo, A., Ballabio, A., & Sguotti, C. (1991). Effects of High-Dose IgG on Survival of Surgical Patients with Sepsis Scores of 20 or Greater. Archives of Surgery, 126(2), 236-240. https://doi.org/10.1001/archsurg.1991.01410260126018