Abstract
Background: Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. Aim: To evaluate the effect of highly purified FSH (hpFSH) administration on standard semen parameters, sperm oxidative stress, and sperm chromatin structure and DNA fragmentation. Material and methods: In the current prospective baseline-controlled study, 36 subjects with male idiophatic infertility were enrolled. Baseline clinical and biochemical data were evaluated. Before and after 3 months of treatment with hpFSH, sperm samples were collected and standard semen analysis, reactive oxygen species (ROS) assessment and sperm DNA fragmentation were evaluated. Results: A significant (p
Original language | English |
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Pages (from-to) | 747-752 |
Number of pages | 6 |
Journal | Journal of Endocrinological Investigation |
Volume | 34 |
Issue number | 10 |
DOIs | |
Publication status | Published - Nov 2011 |
Keywords
- DNA fragmentation
- Gonadotropins
- hpFSH
- Male infertility
- ROS
- Subfertility
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology