Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility: A pilot study

S. Palomba, A. Falbo, S. Espinola, M. Rocca, S. Capasso, F. Cappiello, F. Zullo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. Aim: To evaluate the effect of highly purified FSH (hpFSH) administration on standard semen parameters, sperm oxidative stress, and sperm chromatin structure and DNA fragmentation. Material and methods: In the current prospective baseline-controlled study, 36 subjects with male idiophatic infertility were enrolled. Baseline clinical and biochemical data were evaluated. Before and after 3 months of treatment with hpFSH, sperm samples were collected and standard semen analysis, reactive oxygen species (ROS) assessment and sperm DNA fragmentation were evaluated. Results: A significant (p

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalJournal of Endocrinological Investigation
Volume34
Issue number10
DOIs
Publication statusPublished - Nov 2011

Keywords

  • DNA fragmentation
  • Gonadotropins
  • hpFSH
  • Male infertility
  • ROS
  • Subfertility

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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