Abstract
Background: Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. Aim: To evaluate the effect of highly purified FSH (hpFSH) administration on standard semen parameters, sperm oxidative stress, and sperm chromatin structure and DNA fragmentation. Material and methods: In the current prospective baseline-controlled study, 36 subjects with male idiophatic infertility were enrolled. Baseline clinical and biochemical data were evaluated. Before and after 3 months of treatment with hpFSH, sperm samples were collected and standard semen analysis, reactive oxygen species (ROS) assessment and sperm DNA fragmentation were evaluated. Results: A significant (p
| Original language | English |
|---|---|
| Pages (from-to) | 747-752 |
| Number of pages | 6 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 34 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 2011 |
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Keywords
- DNA fragmentation
- Gonadotropins
- hpFSH
- Male infertility
- ROS
- Subfertility
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility : A pilot study. / Palomba, S.; Falbo, A.; Espinola, S.; Rocca, M.; Capasso, S.; Cappiello, F.; Zullo, F.
In: Journal of Endocrinological Investigation, Vol. 34, No. 10, 11.2011, p. 747-752.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility
T2 - A pilot study
AU - Palomba, S.
AU - Falbo, A.
AU - Espinola, S.
AU - Rocca, M.
AU - Capasso, S.
AU - Cappiello, F.
AU - Zullo, F.
PY - 2011/11
Y1 - 2011/11
N2 - Background: Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. Aim: To evaluate the effect of highly purified FSH (hpFSH) administration on standard semen parameters, sperm oxidative stress, and sperm chromatin structure and DNA fragmentation. Material and methods: In the current prospective baseline-controlled study, 36 subjects with male idiophatic infertility were enrolled. Baseline clinical and biochemical data were evaluated. Before and after 3 months of treatment with hpFSH, sperm samples were collected and standard semen analysis, reactive oxygen species (ROS) assessment and sperm DNA fragmentation were evaluated. Results: A significant (p
AB - Background: Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. Aim: To evaluate the effect of highly purified FSH (hpFSH) administration on standard semen parameters, sperm oxidative stress, and sperm chromatin structure and DNA fragmentation. Material and methods: In the current prospective baseline-controlled study, 36 subjects with male idiophatic infertility were enrolled. Baseline clinical and biochemical data were evaluated. Before and after 3 months of treatment with hpFSH, sperm samples were collected and standard semen analysis, reactive oxygen species (ROS) assessment and sperm DNA fragmentation were evaluated. Results: A significant (p
KW - DNA fragmentation
KW - Gonadotropins
KW - hpFSH
KW - Male infertility
KW - ROS
KW - Subfertility
UR - http://www.scopus.com/inward/record.url?scp=84856857238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856857238&partnerID=8YFLogxK
U2 - 10.3275/7745
DO - 10.3275/7745
M3 - Article
C2 - 21606671
AN - SCOPUS:84856857238
VL - 34
SP - 747
EP - 752
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 10
ER -