Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility: A pilot study

S. Palomba; A. Falbo; S. Espinola; M. Rocca; S. Capasso; F. Cappiello; F. Zullo

doi:10.3275/7745

Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility: A pilot study

S. Palomba, A. Falbo, S. Espinola, M. Rocca, S. Capasso, F. Cappiello, F. Zullo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Gonadotropins administration have been demonstrated effective for the treatment of idiopathic male infertility, even if no clear data regarding their specific mechanism of action on semen quality are at the moment available. Aim: To evaluate the effect of highly purified FSH (hpFSH) administration on standard semen parameters, sperm oxidative stress, and sperm chromatin structure and DNA fragmentation. Material and methods: In the current prospective baseline-controlled study, 36 subjects with male idiophatic infertility were enrolled. Baseline clinical and biochemical data were evaluated. Before and after 3 months of treatment with hpFSH, sperm samples were collected and standard semen analysis, reactive oxygen species (ROS) assessment and sperm DNA fragmentation were evaluated. Results: A significant (p

Original language	English
Pages (from-to)	747-752
Number of pages	6
Journal	Journal of Endocrinological Investigation
Volume	34
Issue number	10
DOIs	https://doi.org/10.3275/7745
Publication status	Published - Nov 2011

Keywords

DNA fragmentation
Gonadotropins
hpFSH
Male infertility
ROS
Subfertility

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility : A pilot study. / Palomba, S.; Falbo, A.; Espinola, S.; Rocca, M.; Capasso, S.; Cappiello, F.; Zullo, F.

In: Journal of Endocrinological Investigation, Vol. 34, No. 10, 11.2011, p. 747-752.

Research output: Contribution to journal › Article › peer-review

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AU - Capasso, S.

AU - Cappiello, F.

AU - Zullo, F.

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