Effects of hormonal replacement therapy in postmenopausal hypertensive patients

Pietro Affinito, Stefano Palomba, Marika Bonifacio, Dario Fontana, Raffaele Izzo, Bruno Trimarco, Carmine Nappi

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of hormonal replacement therapy (HRT) on blood pressure (BP) in postmenopausal hypertensive women. Methods: Sixty women affected by hypertension were enrolled and randomized in two groups of treatment: transdermal continuous HRT in a sequential regimen (group A) and placebo (group P). At baseline, after 3 and 6 months of treatment, the BP with standard sphygmomanometer and with 24-h ambulatory recording method was evaluated in two periods (from day 10 through day 16 of the cycle and from day 20 through day 27 of the cycle). At the same time, we also evaluated total cholesterol, LDL-c, HDL-c, triglycerides, and fibrinogen levels. Results: After 3 and 6 months of treatment, no significant variations of systolic and diastolic BP measured with standard sphygmomanometer were detected in both groups. On the contrary, in group A in comparison with basal values and group P, and without difference between the two phases of treatment, the 24-h recording showed a significant (P <0.05) decrease in BP. No significant variations were detected in group P versus baseline. In particular, we observed in group A at 3 months of treatment a significant (P <0.05) decrease only in daytime BP in comparison with basal values and group P, without difference between the two phases of treatment. Indeed, the decrease in daytime BP was significant (P <0.05) for both systolic and diastolic BP. At 3 and 6 months a significant (P

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalMaturitas
Volume40
Issue number1
DOIs
Publication statusPublished - Oct 31 2001

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Keywords

  • Cardiovascular disease
  • Hormone replacement therapy
  • HRT
  • Hypertension
  • Postmenopause

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

Cite this

Affinito, P., Palomba, S., Bonifacio, M., Fontana, D., Izzo, R., Trimarco, B., & Nappi, C. (2001). Effects of hormonal replacement therapy in postmenopausal hypertensive patients. Maturitas, 40(1), 75-83. https://doi.org/10.1016/S0378-5122(01)00196-7