TY - JOUR
T1 - Effects of human T-cell leukemia virus type 1 (HTLV-1) p13 on mitochondrial K+ permeability
T2 - A new member of the viroporin family?
AU - Silic-Benussi, Micol
AU - Marin, Oriano
AU - Biasiotto, Roberta
AU - D'Agostino, Donna M.
AU - Ciminale, Vincenzo
PY - 2010/5
Y1 - 2010/5
N2 - Human T-cell leukemia virus type-1 (HTLV-1) encodes a mitochondrial protein named p13. p13 mediates an inward K+ current in isolated mitochondria that leads to mitochondrial swelling, depolarization, increased respiratory chain activity and reactive oxygen species (ROS) production. These effects trigger the opening of the permeability transition pore and are dependent on the presence of K+ and on the amphipathic alpha helical domain of p13. In the context of cells, p13 acts as a sensitizer to selected apoptotic stimuli. Although it is not known whether p13 influences the activity of endogenous K+ channels or forms a channel itself, it shares some structural and functional analogies with viroporins, a class of small integral membrane proteins that form pores and alter membrane permeability.
AB - Human T-cell leukemia virus type-1 (HTLV-1) encodes a mitochondrial protein named p13. p13 mediates an inward K+ current in isolated mitochondria that leads to mitochondrial swelling, depolarization, increased respiratory chain activity and reactive oxygen species (ROS) production. These effects trigger the opening of the permeability transition pore and are dependent on the presence of K+ and on the amphipathic alpha helical domain of p13. In the context of cells, p13 acts as a sensitizer to selected apoptotic stimuli. Although it is not known whether p13 influences the activity of endogenous K+ channels or forms a channel itself, it shares some structural and functional analogies with viroporins, a class of small integral membrane proteins that form pores and alter membrane permeability.
KW - Apoptosis
KW - Calcium homeostasis
KW - HTLV-1
KW - Leukemia
KW - Mitochondria
KW - Potassium channel
KW - Viroporin
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U2 - 10.1016/j.febslet.2010.02.030
DO - 10.1016/j.febslet.2010.02.030
M3 - Article
C2 - 20170654
AN - SCOPUS:77952673390
VL - 584
SP - 2070
EP - 2075
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 10
ER -