Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Ferdinando Nicoletti, G. Dementi, A. Prato, P. L. Canonico, L. Rampello, F. Patti, R. M. Di Giorgio, U. Scapagnini

Research output: Contribution to journalArticle

Abstract

Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroendocrinology
Volume36
Issue number1
DOIs
Publication statusPublished - 1983

Keywords

  • Glutamic acid decarboxylase
  • Medial basal hypothalamus
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat'. Together they form a unique fingerprint.

  • Cite this

    Nicoletti, F., Dementi, G., Prato, A., Canonico, P. L., Rampello, L., Patti, F., Di Giorgio, R. M., & Scapagnini, U. (1983). Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat. Neuroendocrinology, 36(1), 13-16. https://doi.org/10.1159/000123430