Effects of Hypericum Perforatum, in a rodent model of periodontitis

Irene Paterniti, Enrico Briguglio, Emanuela Mazzon, Maria Galuppo, Giacomo Oteri, Giancarlo Cordasco, Salvatore Cuzzocrea

Research output: Contribution to journalArticlepeer-review


Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis.Methods: Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.Results: Periodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above.Conclusions: Taken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.

Original languageEnglish
Article number73
JournalBMC Complementary and Alternative Medicine
Publication statusPublished - Nov 23 2010

ASJC Scopus subject areas

  • Complementary and alternative medicine


Dive into the research topics of 'Effects of Hypericum Perforatum, in a rodent model of periodontitis'. Together they form a unique fingerprint.

Cite this